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Details on Person Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities

Class:IdLiteratureReference:70926
_displayNameFamilial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
_timestamp2003-10-30 07:42:37
author[Person:70927] Markovitz, PJ
[Person:70025] Chuang, DT
[Person:70928] Cox, RP
journalJ Biol Chem
pages11643-6
pubMedIdentifier6434529
titleFamilial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
volume259
year1984
(literatureReference)[CatalystActivityReference:9643643] saccharopine dehydrogenase (NADP+, L-lysine-forming) activity of AASS tetramer [mitochondrial matrix] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
[CatalystActivityReference:9643995] saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity of AASS tetramer [mitochondrial matrix] Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities
[Reaction:70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O [Homo sapiens]
[Reaction:70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ [Homo sapiens]
[Pathway:71064] Lysine catabolism [Homo sapiens]
[Complex:70925] AASS tetramer [mitochondrial matrix] [Homo sapiens]
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No pathways have been reviewed or authored by Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities (70926)