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Details on Person N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate

Class:Id	Reaction:70920
_displayName	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate
_doRelease	TRUE
_timestamp	2024-10-28 22:29:15
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70917] formimidoyltetrahydrofolate cyclodeaminase activity of FTCD octamer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643812] formimidoyltetrahydrofolate cyclodeaminase activity of FTCD octamer [cytosol] The molecular basis of glutamate formiminotransferase deficiency
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9925940] RHEA:15099
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:30158] NF-Glu [cytosol] [SimpleEntity:111355] THF [cytosol]
literatureReference	[LiteratureReference:517423] The molecular basis of glutamate formiminotransferase deficiency [LiteratureReference:70909] The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli [LiteratureReference:70913] Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:517430] D'Eustachio, P, 2010-02-18 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:1080816] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
name	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate
output	[SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:70919] FITHF [cytosol]
precedingEvent	[Reaction:70906] 4-imidazolone-5-propanoate + H2O => N-formiminoglutamate [Homo sapiens] [Reaction:70903] urocanate + H2O => 4-imidazolone-5-propanoate [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360999] R-HSA-70920.5
summation	[Summation:178963] Cytosolic formimidoyltransferase-cyclodeaminase (FTCD) catal...
(hasEvent)	[Pathway:70921] Histidine catabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791206] Update Tracker - [Reaction:70920] N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate - v32:[addLiteratureReference, modifyText]
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