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Details on Person methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+

Class:IdReaction:70893
_displayNamemethylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+
_doReleaseTRUE
_timestamp2024-12-03 20:53:26
catalystActivity[CatalystActivity:70892] methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity of ALDH6A1 [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9925935] RHEA:76628
input[SimpleEntity:30004] 2M3OPROA [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
[SimpleEntity:29374] CoA-SH [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
literatureReference[LiteratureReference:508470] Molecular characterization of methylmalonate semialdehyde dehydrogenase deficiency
[LiteratureReference:508475] CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:508464] D'Eustachio, P, 2010-02-12
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9917363] D'Eustachio, Peter, 2024-08-02
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
[InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31
[InstanceEdit:9927658] D'Eustachio, Peter, 2024-11-08
[InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
namemethylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+
(S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA
negativePrecedingEvent[NegativePrecedingEvent:9930371] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
output[SimpleEntity:70843] PROP-CoA [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:29896] HCO3- [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9917333] Hill, David P, 2024-08-02
[InstanceEdit:9927657] D'Eustachio, Peter, 2024-11-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360992] R-HSA-70893.6
structureModified[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
summation[Summation:178951] Mitochondrial methylmalonate semialdehyde dehydrogenase (ALD...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9930391] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+
[Reaction:71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790928] Update Tracker - [Reaction:70893] methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ - v32:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9919402] Update Tracker - [Reaction:70893] methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ - v90:[removeInput]
[_UpdateTracker:9928397] Update Tracker - [Reaction:70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - v91:[add_removeOutput]
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