Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

Class:IdGO_MolecularFunction:70889
_displayNamemethylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
_timestamp2024-05-14 19:07:06
accession0004491
definitionCatalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + hydrogencarbonate + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.
ecNumber1.2.1.27
modified[InstanceEdit:160533] Schmidt, EE, 2005-03-23 05:24:35
[InstanceEdit:162334] Schmidt, EE, 2005-03-23 05:45:22
[InstanceEdit:162607] Schmidt, EE, 2005-04-01 11:06:09
[InstanceEdit:171322] Schmidt, EE, 2006-02-06 10:50:16
[InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20
[InstanceEdit:357819] Kanapin, EE, 2008-06-18 10:45:39
[InstanceEdit:376438] Kanapin, EE, 2008-09-08 10:23:04
[InstanceEdit:383393] Kanapin, AA, 2008-11-26 13:49:44
[InstanceEdit:396309] Kanapin, EE, 2009-03-09 13:26:57
[InstanceEdit:422569] Kanapin, EE
[InstanceEdit:423222] Kanapin, AA
[InstanceEdit:436347] Kanapin, EE
[InstanceEdit:447572] Kanapin, EE
[InstanceEdit:448165] Kanapin, AA
[InstanceEdit:526073] Kanapin, AA
[InstanceEdit:528085] Kanapin, AA
[InstanceEdit:615500] Kanapin, AA
[InstanceEdit:797782] Kanapin, AA
[InstanceEdit:937668] Yung, CK
[InstanceEdit:938674] Yung, CK
[InstanceEdit:1042299] Yung, CK
[InstanceEdit:1043152] Yung, CK
[InstanceEdit:1220942] Yung, CK
[InstanceEdit:1221553] Yung, CK
[InstanceEdit:1301009] Yung, CK
[InstanceEdit:1301023] Yung, CK
[InstanceEdit:1301626] Yung, CK
[InstanceEdit:1552540] Yung, CK
[InstanceEdit:1552982] Yung, CK
[InstanceEdit:1996004] Yung, CK
[InstanceEdit:1996190] Yung, CK
[InstanceEdit:2132408] Weiser, JD
[InstanceEdit:2133145] Weiser, JD
[InstanceEdit:2133759] Yung, CK
[InstanceEdit:2133760] Yung, CK
[InstanceEdit:2133761] Yung, CK
[InstanceEdit:2266115] Yung, CK
[InstanceEdit:2266117] Yung, CK
[InstanceEdit:2266118] Weiser, JD
[InstanceEdit:2266147] Weiser, JD
[InstanceEdit:2267216] Yung, CK
[InstanceEdit:2454362] Weiser, JD
[InstanceEdit:2455542] Weiser, JD
[InstanceEdit:2455544] Yung, CK
[InstanceEdit:2587907] Weiser, JD
[InstanceEdit:2588510] Yung, CK
[InstanceEdit:3132285] Weiser, JD
[InstanceEdit:3132714] Yung, CK
[InstanceEdit:3445953] Weiser, JD
[InstanceEdit:3446290] Yung, CK
[InstanceEdit:4341211] Weiser, JD
[InstanceEdit:4341654] Yung, CK
[InstanceEdit:5083267] Weiser, JD
[InstanceEdit:5083619] Yung, CK
[InstanceEdit:5263134] Weiser, JD
[InstanceEdit:5263568] Yung, CK
[InstanceEdit:5433708] Yung, CK
[InstanceEdit:5619033] Yung, CK
[InstanceEdit:5634717] Yung, CK
[InstanceEdit:5673679] Yung, CK
[InstanceEdit:5692203] Yung, CK
[InstanceEdit:6792433] Yung, CK
[InstanceEdit:6808304] Yung, CK
[InstanceEdit:8857520] Yung, CK
[InstanceEdit:8870260] Yung, CK
[InstanceEdit:8935677] Yung, CK
[InstanceEdit:8945685] Yung, CK
[InstanceEdit:8978846] Yung, CK
[InstanceEdit:9005311] Weiser, JD
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
namemethylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
referenceDatabase[ReferenceDatabase:1] GO
(activity)[CatalystActivity:70892] methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity of ALDH6A1 [mitochondrial matrix]
[CatalystActivity:1118320] methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity of Methylmalonate-semialdehyde dehydrogenase [mitochondrial matrix]
[CatalystActivity:5265690] methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity of AT2G14170 [cytoplasm]
[CatalystActivity:5266474] methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity of 3-chloroallyl aldehyde dehydrogenase [cytoplasm]
[Change default viewing format]
No pathways have been reviewed or authored by methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (70889)
Follow Reactome