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Details on Person beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+

Class:IdReaction:70885
_displayNamebeta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
_doReleaseTRUE
_timestamp2024-10-28 22:29:24
catalystActivity[CatalystActivity:70884] 3-hydroxyisobutyrate dehydrogenase activity of HIBADH tetramer [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9925941] RHEA:31276
input[SimpleEntity:573404] bHIBA [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
literatureReference[LiteratureReference:70886] Purification and properties of beta-hydroxyisobutyric dehydrogenase
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:508464] D'Eustachio, P, 2010-02-12
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:532424] D'Eustachio, P, 2010-02-26
[InstanceEdit:573406] D'Eustachio, P, 2010-04-10
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9908873] Stephan, Ralf, 2024-04-23
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
namebeta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-2-methyl-3-oxopropanoate + H(+) + NADH
negativePrecedingEvent[NegativePrecedingEvent:9908870] Futile Cycle: methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+
output[SimpleEntity:30004] 2M3OPROA [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent
releaseDate2004-07-06
reverseReaction
reviewed[InstanceEdit:532425] Jassal, Bijay, 2010-02-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360014] R-HSA-70885.6
summation[Summation:178504] Mitochondrial 3-hydroxyisobutyrate dehydrogenase (HIBADH) ca...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9908865] Futile Cycle: beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
[Reaction:70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ [Homo sapiens]
(reverseReaction)[Reaction:508473] methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790550] Update Tracker - [Reaction:70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - v33:[add_removeInput]
[_UpdateTracker:9791168] Update Tracker - [Reaction:70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - v32:[modifyText, removeLiteratureReference]
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