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Details on Person ECHS1 hydrates methacrylyl-CoA

Class:IdReaction:70870
_displayNameECHS1 hydrates methacrylyl-CoA
_doReleaseTRUE
_timestamp2024-10-28 22:29:02
catalystActivity[CatalystActivity:71049] enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9672920] enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix] Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9917123] RHEA:31176
input[SimpleEntity:70858] MACR-CoA [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
literatureReference[LiteratureReference:9672910] Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion
modified[InstanceEdit:77455] D'Eustachio, P, 2003-10-28 16:36:00
[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9672919] D'Eustachio, Peter, 2020-01-03
[InstanceEdit:9672924] D'Eustachio, Peter, 2020-01-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
nameECHS1 hydrates methacrylyl-CoA
(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA
methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA
output[SimpleEntity:71847] bHIB-CoA [mitochondrial matrix]
precedingEvent
releaseDate2004-07-06
reviewed[InstanceEdit:9672923] Jassal, Bijay, 2020-01-03
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9672777] D'Eustachio, Peter, 2020-01-02
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361226] R-HSA-70870.6
summation[Summation:178949] Mitochondrial ECHS1 (enoyl-CoA hydratase) hexamer catalyzes ...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(normalReaction)[FailedReaction:9916717] ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA [Homo sapiens]
(precedingEvent)[Reaction:70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777105] Update Tracker - [Reaction:70870] ECHS1 hydrates methacrylyl-CoA - v72:[add_removeCatalystActivity, add_removeLiteratureReference, modifyText]
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No pathways have been reviewed or authored by ECHS1 hydrates methacrylyl-CoA (70870)
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