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Details on Person isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2

Class:IdReaction:70859
_displayNameisobutyryl-CoA + FAD => methacrylyl-CoA + FADH2
_doReleaseTRUE
_timestamp2024-10-28 22:29:32
catalystActivity[CatalystActivity:70857] acyl-CoA dehydrogenase activity of ACAD8 tetramer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643220] acyl-CoA dehydrogenase activity of ACAD8 tetramer [mitochondrial matrix] Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9925946] RHEA:44181
input[SimpleEntity:70851] ISB-CoA [mitochondrial matrix]
[SimpleEntity:113596] FAD [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
literatureReference[LiteratureReference:508471] Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases
[LiteratureReference:70860] Isolated isobutyryl-CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism
[LiteratureReference:70864] Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:508267] D'Eustachio, P, 2010-02-11
[InstanceEdit:508464] D'Eustachio, P, 2010-02-12
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907327] Stephan, Ralf, 2024-04-06
[InstanceEdit:9908873] Stephan, Ralf, 2024-04-23
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9917363] D'Eustachio, Peter, 2024-08-02
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
nameisobutyryl-CoA + FAD => methacrylyl-CoA + FADH2
2-methylpropanoyl-CoA + H(+) + oxidized (electron-transfer flavoprotein) => (2E)-2-methylpropenoyl-CoA + reduced (electron-transfer flavoprotein)
output[SimpleEntity:70858] MACR-CoA [mitochondrial matrix]
[SimpleEntity:31649] FADH2 [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361124] R-HSA-70859.7
structureModified[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
summation[Summation:178918] Mitochondrial isobutyryl-CoA dehydrogenase (ACAD8) catalyzes...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(precedingEvent)[Reaction:70870] ECHS1 hydrates methacrylyl-CoA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791203] Update Tracker - [Reaction:70859] isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 - v32:[addLiteratureReference, modifyText]
[_UpdateTracker:9919407] Update Tracker - [Reaction:70859] isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 - v90:[removeInput]
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No pathways have been reviewed or authored by isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (70859)
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