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Details on Person Muramyl dipeptide (MDP) is an essential structural component...

Class:IdSummation:708347
_displayNameMuramyl dipeptide (MDP) is an essential structural component...
_timestamp2011-04-27 16:05:58
created[InstanceEdit:708351] Jupe, S, 2010-05-11
literatureReference[LiteratureReference:1252400] Activation of innate immune antiviral responses by Nod2
[LiteratureReference:1252402] The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation
modified[InstanceEdit:708355] Jupe, S, 2010-05-11
[InstanceEdit:1247954] Jupe, S, 2011-04-08
[InstanceEdit:1252399] Jupe, S, 2011-04-27
textMuramyl dipeptide (MDP) is an essential structural component of bacterial peptidoglycan (PGN) and the minimal elicitor recognized by NOD2. As MDP is present in nearly all bacteria NOD2 is a general sensor of bacteria. NOD2 has additionally been reported to respond to ssRNA (Sabbah et al. 2009) and play a role in T cell activation (Shaw et al. 2011).
(summation)[Reaction:168412] MDP elicits a NOD2 response [Homo sapiens]
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