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Details on Person beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA

Class:Id	Reaction:70785
_displayName	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA
_doRelease	TRUE
_timestamp	2024-10-28 22:29:29
catalystActivity	[CatalystActivity:70783] methylglutaconyl-CoA hydratase activity of AUH hexamer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643713] methylglutaconyl-CoA hydratase activity of AUH hexamer [mitochondrial matrix] 3-Methylglutaconic aciduria type I is caused by mutations in AUH.
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9917115] RHEA:21538
input	[SimpleEntity:70772] bMG-CoA [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix]
literatureReference	[LiteratureReference:70776] 3-Methylglutaconic aciduria type I is caused by mutations in AUH. [LiteratureReference:508311] Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase [LiteratureReference:70789] Deficiency of 3-methylglutaconyl-coenzyme A hydratase in two siblings with 3-methylglutaconic aciduria
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:508306] D'Eustachio, P, 2010-02-11 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9907327] Stephan, Ralf, 2024-04-06 [InstanceEdit:9908873] Stephan, Ralf, 2024-04-23 [InstanceEdit:9917131] Stephan, Ralf, 2024-07-30 [InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
name	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA 3-methyl-(2E)-glutaconyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA
output	[SimpleEntity:70784] bHMG-CoA [mitochondrial matrix]
precedingEvent	[Reaction:70773] beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA) [Homo sapiens] [Reaction:70745] isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359968] R-HSA-70785.7
summation	[Summation:178507] Mitochondrial ethylglutaconyl-CoA hydratase (AUH) catalyzes ...
(hasEvent)	[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(normalReaction)	[FailedReaction:9914271] AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791102] Update Tracker - [Reaction:70785] beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA - v32:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9919398] Update Tracker - [Reaction:70785] beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA - v90:[modifyText]
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No pathways have been reviewed or authored by beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (70785)