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Details on Person beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)

Class:IdReaction:70773
_displayNamebeta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)
_doReleaseTRUE
_timestamp2024-12-03 20:53:17
catalystActivity[CatalystActivity:70771] methylcrotonoyl-CoA carboxylase activity of 6x(Btn-MCCC1:MCCC2) [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643717] methylcrotonoyl-CoA carboxylase activity of 6x(Btn-MCCC1:MCCC2) [mitochondrial matrix] The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9925947] RHEA:13590
input[SimpleEntity:70744] bMC-CoA [mitochondrial matrix]
[SimpleEntity:113593] ATP [mitochondrial matrix]
[SimpleEntity:29896] HCO3- [mitochondrial matrix]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
literatureReference[LiteratureReference:70761] The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency
[LiteratureReference:1112670] Subcellular localization of 3-methylcrotonyl-coenzyme A carboxylase in bovine kidney
[LiteratureReference:70749] Cloning of the human MCCA and MCCB genes and mutations therein reveal the molecular cause of 3-methylcrotonyl-CoA: carboxylase deficiency
[LiteratureReference:1112677] Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase
modified[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:508306] D'Eustachio, P, 2010-02-11
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:580603] D'Eustachio, P, 2010-04-11
[InstanceEdit:1112674] D'Eustachio, P, 2010-12-08
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8981172] Duenas, Corina, 2017-03-03
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907327] Stephan, Ralf, 2024-04-06
[InstanceEdit:9908873] Stephan, Ralf, 2024-04-23
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9919308] D'Eustachio, Peter, 2024-08-20
[InstanceEdit:9919317] D'Eustachio, Peter, 2024-08-21
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
[InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
namebeta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)
3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate => 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate
negativePrecedingEvent[NegativePrecedingEvent:9908863] Futile Cycle: beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA)
[NegativePrecedingEvent:9930391] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+
output[SimpleEntity:70772] bMG-CoA [mitochondrial matrix]
[SimpleEntity:113581] ADP [mitochondrial matrix]
[SimpleEntity:113548] Pi [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reverseReaction
reviewed[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359855] R-HSA-70773.9
structureModified[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
summation[Summation:178506] Methylcrotonyl CoA carboxylase (MCCA) catalyzes the reversib...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(normalReaction)[FailedReaction:9909466] MCCC mutants don't synthesize beta-methylglutaconyl-CoA [Homo sapiens]
(precedingEvent)[Reaction:70785] beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA [Homo sapiens]
[NegativePrecedingEvent:9908866] Futile Cycle: beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)
(reverseReaction)[Reaction:508308] beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9789910] Update Tracker - [Reaction:70773] beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] - v36:[addLiteratureReference, modifyText]
[_UpdateTracker:9790396] Update Tracker - [Reaction:70773] beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] - v33:[add_removeInput, removeOutput]
[_UpdateTracker:9791078] Update Tracker - [Reaction:70773] beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] - v32:[modifyText]
[_UpdateTracker:9919348] Update Tracker - [Reaction:70773] beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] - v90:[modifyText, removeOutput]
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