Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2

Class:IdReaction:70745
_displayNameisovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2
_doReleaseTRUE
_timestamp2024-10-28 22:29:33
catalystActivity[CatalystActivity:70743] 3-methylbutanoyl-CoA dehydrogenase activity of IVD tetramer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9644049] isovaleryl-CoA dehydrogenase activity of IVD tetramer [mitochondrial matrix] Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9917119] RHEA:12277
input[SimpleEntity:70715] ISV-CoA [mitochondrial matrix]
[SimpleEntity:113596] FAD [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
internalReviewed[InstanceEdit:9917225] D'Eustachio, Peter, 2024-08-01
literatureReference[LiteratureReference:70739] Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver
[LiteratureReference:70746] Demonstration of a specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in fibroblasts from patients with isovaleric acidemia
[LiteratureReference:70731] Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:508267] D'Eustachio, P, 2010-02-11
[InstanceEdit:508306] D'Eustachio, P, 2010-02-11
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907327] Stephan, Ralf, 2024-04-06
[InstanceEdit:9908873] Stephan, Ralf, 2024-04-23
[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
[InstanceEdit:9919308] D'Eustachio, Peter, 2024-08-20
[InstanceEdit:9919317] D'Eustachio, Peter, 2024-08-21
[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
nameisovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2
3-methylbutanoyl-CoA + H(+) + oxidized (electron-transfer flavoprotein) => 3-methyl-(2E)-butenoyl-CoA + reduced (electron-transfer flavoprotein)
output[SimpleEntity:70744] bMC-CoA [mitochondrial matrix]
[SimpleEntity:31649] FADH2 [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9919316] D'Eustachio, Peter, 2024-08-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359090] R-HSA-70745.7
structureModified[InstanceEdit:9917131] Stephan, Ralf, 2024-07-30
summation[Summation:178922] Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the r...
(hasEvent)[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(normalReaction)[FailedReaction:9914837] IVD mutants don't synthesize beta-methylcrotonyl-CoA [Homo sapiens]
(precedingEvent)[Reaction:70773] beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791165] Update Tracker - [Reaction:70745] isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 - v32:[addLiteratureReference, modifyText]
[_UpdateTracker:9919378] Update Tracker - [Reaction:70745] isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 - v90:[modifyText, removeInput]
[Change default viewing format]
No pathways have been reviewed or authored by isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (70745)
Follow Reactome