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Details on Person leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]

Class:Id	Reaction:70723
_displayName	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
_doRelease	TRUE
_timestamp	2024-10-25 22:01:11
catalystActivity	[CatalystActivity:70700] branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643740] branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol] Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9917060] RHEA:18322 [DatabaseIdentifier:9917056] RHEA:24802 [DatabaseIdentifier:9917057] RHEA:24814
input	[DefinedSet:508182] Leu, Ile, Val [cytosol] [SimpleEntity:29406] 2OG [cytosol]
literatureReference	[LiteratureReference:508185] Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:508183] D'Eustachio, P, 2010-02-10 [InstanceEdit:508233] D'Eustachio, P, 2010-02-11 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9908873] Stephan, Ralf, 2024-04-23 [InstanceEdit:9917064] Stephan, Ralf, 2024-07-30 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
name	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] 2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate 2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate 2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate
negativePrecedingEvent	[NegativePrecedingEvent:9908871] Futile Cycle: a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]
output	[DefinedSet:508187] KIC,KMVA,KIV [cytosol] [SimpleEntity:29404] L-Glu [cytosol]
releaseDate	2004-07-06
reverseReaction	[Reaction:508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] [Homo sapiens] [Reaction:70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360870] R-HSA-70723.7
summation	[Summation:178919] Cytosolic branched-chain-amino-acid aminotransferase (BCAT1)...
(hasEvent)	[Pathway:70895] Branched-chain amino acid catabolism [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9908872] Futile Cycle: leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] [Reaction:210444] L-Glutamate loading of synaptic vesicle [Homo sapiens] [Reaction:9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV [Homo sapiens]
(replacementInstances)	[_Deleted:508194] Deletion of instance: 70847 [_Deleted:513019] Deletion of instance: 70702
(reverseReaction)	[Reaction:508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777342] Update Tracker - [Reaction:70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] - v72:[modifyText] [_UpdateTracker:9791000] Update Tracker - [Reaction:70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] - v32:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (70723)