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Details on Person ALDH4A1 oxidises L-GluSS to Glu

Class:IdReaction:70679
_displayNameALDH4A1 oxidises L-GluSS to Glu
_doReleaseTRUE
_timestamp2025-02-25 22:16:23
authored[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity[CatalystActivity:70678] L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643321] 1-pyrroline-5-carboxylate dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix] Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9929428] RHEA:30236
edited[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input[SimpleEntity:31339] L-Glu5S [mitochondrial matrix]
[SimpleEntity:113526] NAD+ [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
internalReviewed[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
literatureReference[LiteratureReference:70675] Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase.
[LiteratureReference:70681] Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia.
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:584171] D'Eustachio, P, 2010-04-11
[InstanceEdit:1080817] D'Eustachio, P, 2010-11-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8955816] Jassal, Bijay, 2017-01-13
[InstanceEdit:8955828] Jassal, Bijay, 2017-01-13
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
[InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06
[InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
nameALDH4A1 oxidises L-GluSS to Glu
H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH
L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+
output[SimpleEntity:113552] L-Glu [mitochondrial matrix]
[SimpleEntity:29362] NADH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358957] R-HSA-70679.6
structureModified[InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
summation[Summation:70680] Mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenase ...
(hasEvent)[Pathway:70688] Proline catabolism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790476] Update Tracker - [Reaction:70679] ALDH4A1 oxidises L-GluSS to Glu - v33:[addInput]
[_UpdateTracker:9790916] Update Tracker - [Reaction:70679] ALDH4A1 oxidises L-GluSS to Glu - v32:[modifyText]
[_UpdateTracker:9792273] Update Tracker - [Reaction:70679] ALDH4A1 oxidises L-GluSS to Glu - v22:[addLiteratureReference]
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