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Details on Person PRODH oxidises L-Pro to 1PYR-5COOH

Class:IdReaction:70670
_displayNamePRODH oxidises L-Pro to 1PYR-5COOH
_doReleaseTRUE
_timestamp2025-02-25 22:17:11
authored[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity[CatalystActivity:70669] oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor of PRODH [mitochondrial inner membrane]
catalystActivityReference[CatalystActivityReference:9643130] oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor of PRODH [mitochondrial inner membrane] Functional consequences of PRODH missense mutations
compartment[Compartment:5460] mitochondrial matrix
[Compartment:70616] mitochondrial inner membrane
crossReference[DatabaseIdentifier:9929228] RHEA:23785
edited[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input[SimpleEntity:379717] L-Pro [mitochondrial matrix]
[SimpleEntity:113597] FAD [mitochondrial inner membrane]
internalReviewed[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
literatureReference[LiteratureReference:517459] Functional consequences of PRODH missense mutations
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:517454] D'Eustachio, P, 2010-02-18
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:517539] D'Eustachio, P, 2010-02-19
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1080817] D'Eustachio, P, 2010-11-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8955816] Jassal, Bijay, 2017-01-13
[InstanceEdit:8955828] Jassal, Bijay, 2017-01-13
[InstanceEdit:8959641] Jassal, Bijay, 2017-01-30
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929230] D'Eustachio, Peter, 2024-11-22
[InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
[InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06
[InstanceEdit:9939280] D'Eustachio, Peter, 2025-02-22
[InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
namePRODH oxidises L-Pro to 1PYR-5COOH
a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
proline => L-1-pyrroline-5-carboxylate
output[SimpleEntity:113590] 1PYR-5COOH [mitochondrial matrix]
[SimpleEntity:164934] FADH2 [mitochondrial inner membrane]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358310] R-HSA-70670.6
structureModified[InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
summation[Summation:70672] The dehydrogenation (oxidation) of proline to L-1-pyrroline-...
(hasEvent)[Pathway:70688] Proline catabolism [Homo sapiens]
(precedingEvent)[Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781642] Update Tracker - [Reaction:70670] PRODH oxidises L-Pro to 1PYR-5COOH - v60:[addOutput, modifyText]
[_UpdateTracker:9790943] Update Tracker - [Reaction:70670] PRODH oxidises L-Pro to 1PYR-5COOH - v32:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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