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Details on Person 1PYR-5COOH spontaneously hydrolyses to L-GluSS

Class:Id	Reaction:70667
_displayName	1PYR-5COOH spontaneously hydrolyses to L-GluSS
_doRelease	TRUE
_timestamp	2024-11-26 00:03:25
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9929434] RHEA:28236
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:113590] 1PYR-5COOH [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix]
literatureReference	[Book:70631] The hyperornithinemias 0079130356 Scriver, Charles R The Metabolic and Molecular Bases of Inherited Disease, 8th ed
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:584171] D'Eustachio, P, 2010-04-11 [InstanceEdit:1080817] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8955816] Jassal, Bijay, 2017-01-13 [InstanceEdit:8955828] Jassal, Bijay, 2017-01-13 [InstanceEdit:8964541] Jassal, Bijay, 2017-02-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
name	1PYR-5COOH spontaneously hydrolyses to L-GluSS (S)-1-pyrroline-5-carboxylate + H(+) + H2O => L-glutamate 5-semialdehyde
output	[SimpleEntity:31339] L-Glu5S [mitochondrial matrix]
precedingEvent	[Reaction:70670] PRODH oxidises L-Pro to 1PYR-5COOH [Homo sapiens] [Reaction:8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate [Homo sapiens] [Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359215] R-HSA-70667.5
summation	[Summation:178925] The interconversion of (S)-1-pyrroline-5-carboxylate (1PYR-5...
(hasEvent)	[Pathway:70688] Proline catabolism [Homo sapiens]
(precedingEvent)	[Reaction:70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] [Homo sapiens] [Reaction:70679] ALDH4A1 oxidises L-GluSS to Glu [Homo sapiens]
(reverseReaction)	[Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781758] Update Tracker - [Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS - v60:[modifyText] [_UpdateTracker:9790484] Update Tracker - [Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS - v33:[addInput] [_UpdateTracker:9791101] Update Tracker - [Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS - v32:[modifyText]
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