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Details on Person glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]

Class:Id	Reaction:70666
_displayName	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
_doRelease	TRUE
_timestamp	2024-12-03 20:53:20
catalystActivity	[CatalystActivity:70653] ornithine aminotransferase activity of OAT hexamer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643733] ornithine-oxo-acid transaminase activity of OAT hexamer [mitochondrial matrix] Crystallization and properties of human liver ornithine aminotransferase
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9925800] RHEA:25162
input	[SimpleEntity:113552] L-Glu [mitochondrial matrix] [SimpleEntity:31339] L-Glu5S [mitochondrial matrix]
literatureReference	[LiteratureReference:70640] Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences. [Book:70631] The hyperornithinemias 0079130356 Scriver, Charles R The Metabolic and Molecular Bases of Inherited Disease, 8th ed
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:508032] D'Eustachio, P, 2010-02-10 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
name	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] L-glutamate + L-glutamate 5-semialdehyde => 2-oxoglutarate + L-ornithine
negativePrecedingEvent	[NegativePrecedingEvent:9930385] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) [NegativePrecedingEvent:9930389] Futile Cycle: ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]
output	[SimpleEntity:113585] L-Orn [mitochondrial matrix] [SimpleEntity:113594] 2OG [mitochondrial matrix]
precedingEvent	[Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS [Homo sapiens] [Reaction:70670] PRODH oxidises L-Pro to 1PYR-5COOH [Homo sapiens] [Reaction:8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH [Homo sapiens] [Reaction:508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] [Homo sapiens] [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [BlackBoxEvent:212651] Transport of L-Glutamine (cytosol) to mitochondrial matrix [Homo sapiens] [Reaction:212614] Glutamine transport from astrocytes [Homo sapiens] [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens] [Reaction:70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358753] R-HSA-70666.6
summation	[Summation:178808] Mitochondrial ornithine aminotransferase (OAT) catalyzes the...
(hasEvent)	[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(precedingEvent)	[Reaction:70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate [Homo sapiens] [NegativePrecedingEvent:9930368] Futile Cycle: glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] [NegativePrecedingEvent:9930388] Futile Cycle: glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
(reverseReaction)	[Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791135] Update Tracker - [Reaction:70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - v32:[modifyText]
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No pathways have been reviewed or authored by glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (70666)