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Details on Person PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

Class:Id	Reaction:70664
_displayName	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
_doRelease	TRUE
_timestamp	2024-12-03 20:53:02
catalystActivity	[CatalystActivity:70663] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643684] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix] Functional specialization in proline biosynthesis of melanoma
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9925790] RHEA:14107
input	[SimpleEntity:113590] 1PYR-5COOH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:29362] NADH [mitochondrial matrix]
internalReviewed	[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
literatureReference	[LiteratureReference:6783923] Functional specialization in proline biosynthesis of melanoma [LiteratureReference:508083] Crystal structure of human pyrroline-5-carboxylate reductase [LiteratureReference:508064] Mutations in PYCR1 cause cutis laxa with progeroid features
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:508032] D'Eustachio, P, 2010-02-10 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:6783706] D'Eustachio, Peter, 2015-06-16 [InstanceEdit:6783707] D'Eustachio, Peter, 2015-06-16 [InstanceEdit:6783708] D'Eustachio, Peter, 2015-06-16 [InstanceEdit:6783922] D'Eustachio, Peter, 2015-06-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31 [InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08 [InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
name	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro 1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)
negativePrecedingEvent	[NegativePrecedingEvent:9930370] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
output	[SimpleEntity:379717] L-Pro [mitochondrial matrix] [SimpleEntity:113526] NAD+ [mitochondrial matrix]
precedingEvent	[Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate [Homo sapiens] [Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens] [Reaction:508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361550] R-HSA-70664.7
structureModified	[InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
summation	[Summation:178924] Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the re...
(hasEvent)	[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(precedingEvent)	[Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784405] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v54:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [_UpdateTracker:9791183] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9928431] Update Tracker - [Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v91:[modifyText]
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