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Details on Person L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate

Class:Id	Reaction:70655
_displayName	L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate
_doRelease	TRUE
_timestamp	2024-11-08 15:22:52
compartment	[Compartment:5460] mitochondrial matrix
input	[SimpleEntity:31339] L-Glu5S [mitochondrial matrix]
internalReviewed	[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
literatureReference	[Book:70631] The hyperornithinemias 0079130356 Scriver, Charles R The Metabolic and Molecular Bases of Inherited Disease, 8th ed
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:508032] D'Eustachio, P, 2010-02-10 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:584171] D'Eustachio, P, 2010-04-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31 [InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
name	L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O
output	[SimpleEntity:113590] 1PYR-5COOH [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens] [Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Homo sapiens] [Reaction:508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] [Homo sapiens] [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reverseReaction	[Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS [Homo sapiens] [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate [Homo sapiens]
reviewed	[InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359190] R-HSA-70655.4
structureModified	[InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
summation	[Summation:178926] The interconversion of glutamate 5-semialdehyde (L-GluSS) an...
(hasEvent)	[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(precedingEvent)	[Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Homo sapiens] [Reaction:6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Homo sapiens] [Reaction:6783955] PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Homo sapiens]
(reverseReaction)	[Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781955] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v60:[modifyText] [_UpdateTracker:9790575] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v33:[addOutput] [_UpdateTracker:9791174] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v32:[modifyText] [_UpdateTracker:9928423] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v91:[removeOutput]
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