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Details on Person ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)

Class:IdReaction:70634
_displayNameornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
_doReleaseTRUE
_timestamp2025-12-31 17:58:50
authored[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity[CatalystActivity:70633] L-ornithine transmembrane transporter activity of Mitochondrial ornithine transporters [mitochondrial inner membrane]
catalystActivityReference[CatalystActivityReference:9643582] L-ornithine transmembrane transporter activity of Mitochondrial ornithine transporters [mitochondrial inner membrane] The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
compartment[Compartment:70101] cytosol
[Compartment:70616] mitochondrial inner membrane
[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9978418] RHEA:70787
edited[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input[SimpleEntity:113567] L-Cit [mitochondrial matrix]
[SimpleEntity:29498] L-Orn [cytosol]
[SimpleEntity:113529] H+ [mitochondrial matrix]
internalReviewed[InstanceEdit:9978421] D'Eustachio, Peter, 2025-12-31
literatureReference[LiteratureReference:70619] Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter
[LiteratureReference:374019] The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
[LiteratureReference:449686] Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder
modified[InstanceEdit:113652] Schmidt, EE, 2004-06-11 08:58:20
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:374021] D'Eustachio, P, 2008-07-24 20:44:45
[InstanceEdit:374024] D'Eustachio, P, 2008-07-24 21:06:09
[InstanceEdit:449690] D'Eustachio, P, 2009-12-05
[InstanceEdit:452030] D'Eustachio, P, 2010-01-14
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:1080818] D'Eustachio, P, 2010-11-27
[InstanceEdit:1667321] D'Eustachio, P, 2011-10-14
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9978417] Gupta, Parul, 2025-12-31
[InstanceEdit:9978420] Gupta, Parul, 2025-12-31
[InstanceEdit:9978424] Gupta, Parul, 2025-12-31
nameornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
L-citrulline(in) + L-ornithine(out) + H(+)(in) = L-citrulline(out) + L-ornithine(in) + H(+)(out)
output[SimpleEntity:29968] L-Cit [cytosol]
[SimpleEntity:113585] L-Orn [mitochondrial matrix]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9978423] D'Eustachio, Peter, 2025-12-31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359721] R-HSA-70634.5
structureModified[InstanceEdit:9978417] Gupta, Parul, 2025-12-31
summation[Summation:179015] The mitochondrial ornithine transporters SLC25A15 and SLC25A...
(hasEvent)[Pathway:70635] Urea cycle [Homo sapiens]
(inferredFrom)[Reaction:187608] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Gallus gallus]
(normalReaction)[FailedReaction:9956519] SLC25A15 variants don't translocate ornithine and citrulline [Homo sapiens]
(precedingEvent)[Reaction:70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate [Homo sapiens]
[Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Homo sapiens]
[Reaction:70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791003] Update Tracker - [Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - v32:[addLiteratureReference]
[_UpdateTracker:9791769] Update Tracker - [Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - v26:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9984648] Update Tracker - [Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - v96:[removeInput, removeOutput]
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