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Details on Person GOT2 transaminates OA and L-Glu

Class:Id	Reaction:70613
_displayName	GOT2 transaminates OA and L-Glu
_doRelease	TRUE
_timestamp	2024-12-03 20:52:46
catalystActivity	[CatalystActivity:70595] L-aspartate:2-oxoglutarate transaminase activity of GOT2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643893] L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix] Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9856887] RHEA:21826
input	[SimpleEntity:113587] OA [mitochondrial matrix] [SimpleEntity:113552] L-Glu [mitochondrial matrix]
internalReviewed	[InstanceEdit:9857487] D'Eustachio, Peter, 2024-01-07
literatureReference	[LiteratureReference:199763] The primary structure of mitochondrial aspartate aminotransferase from human heart [LiteratureReference:9815355] Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy [LiteratureReference:9857062] Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00 [InstanceEdit:372822] D'Eustachio, P, 2008-07-03 22:07:04 [InstanceEdit:372849] D'Eustachio, P, 2008-07-07 20:55:07 [InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07 [InstanceEdit:507851] D'Eustachio, P, 2010-02-08 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9815402] D'Eustachio, Peter, 2022-08-17 [InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856885] Stephan, Ralf, 2023-12-27 [InstanceEdit:9857061] Stephan, Ralf, 2023-12-31 [InstanceEdit:9857486] Stephan, Ralf, 2024-01-07 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
name	GOT2 transaminates OA and L-Glu L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate GOT2 transaminates oxaloacetate and glutamate
negativePrecedingEvent	[NegativePrecedingEvent:9930379] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) [NegativePrecedingEvent:9930375] Futile Cycle: ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]
output	[SimpleEntity:113553] L-Asp [mitochondrial matrix] [SimpleEntity:113594] 2OG [mitochondrial matrix]
precedingEvent	[Reaction:70501] PC carboxylates PYR to OA [Homo sapiens] [Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens] [Reaction:9012268] ME2 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:9861667] DLAT trimer transfers acetyl to CoA [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:372448] SLC25A12,13 exchange L-Glu and L-Asp [Homo sapiens] [Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens] [Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:5693783] NAALADases hydrolyse NAAG [Homo sapiens] [Reaction:8875623] SLC25A18,22 import L-Glu, H+ [Homo sapiens] [Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [BlackBoxEvent:212651] Transport of L-Glutamine (cytosol) to mitochondrial matrix [Homo sapiens] [Reaction:212614] Glutamine transport from astrocytes [Homo sapiens] [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:70596] GOT2 dimer transaminates L-Asp [Homo sapiens] [Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens]
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12 [InstanceEdit:9815859] Hill, David P, 2022-08-29
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359266] R-HSA-70613.9
summation	[Summation:179019] Mitochondrial GOT2 (glutamate oxaloacetate transaminase 2, a...
(hasEvent)	[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens] [Pathway:9856872] Malate-aspartate shuttle [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9930393] Futile Cycle: GOT2 transaminates OA and L-Glu [NegativePrecedingEvent:9930394] Futile Cycle: GOT2 transaminates OA and L-Glu [Reaction:372448] SLC25A12,13 exchange L-Glu and L-Asp [Homo sapiens] [Reaction:372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens]
(reverseReaction)	[Reaction:70596] GOT2 dimer transaminates L-Asp [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790823] Update Tracker - [Reaction:70613] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] - v32:[modifyText] [_UpdateTracker:9791752] Update Tracker - [Reaction:70613] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] - v26:[modifyText] [_UpdateTracker:9792360] Update Tracker - [Reaction:70613] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] - v22:[addLiteratureReference] [_UpdateTracker:9846888] Update Tracker - [Reaction:70613] GOT2 transaminates oxaloacetate and glutamate - v83:[modifyText] [_UpdateTracker:9846992] Update Tracker - [Reaction:70613] GOT2 transaminates oxaloacetate and glutamate - v82:[addLiteratureReference, modifyText] [_UpdateTracker:9864230] Update Tracker - [Reaction:70613] GOT2 transaminates OA and L-Glu - v88:[addLiteratureReference, modifyText]
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