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Details on Person glutamine + H2O => glutamate + NH4+ (GLS)

Class:Id	Reaction:70609
_displayName	glutamine + H2O => glutamate + NH4+ (GLS)
_doRelease	TRUE
_timestamp	2024-10-25 22:01:09
authored	[InstanceEdit:5674609] D'Eustachio, Peter, 2003-05-04
catalystActivity	[CatalystActivity:70608] glutaminase activity of GLS dimers [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9925797] RHEA:15890
edited	[InstanceEdit:660242] D'Eustachio, P, 2010-04-30
input	[SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113522] L-Gln [mitochondrial matrix]
literatureReference	[LiteratureReference:199745] Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing [LiteratureReference:199775] Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase [LiteratureReference:507855] Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00 [InstanceEdit:507851] D'Eustachio, P, 2010-02-08 [InstanceEdit:507856] D'Eustachio, P, 2010-02-08 [InstanceEdit:507864] D'Eustachio, P, 2010-02-08 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:660242] D'Eustachio, P, 2010-04-30 [InstanceEdit:5674610] Orlic-Milacic, Marija, 2015-02-13 [InstanceEdit:8856031] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8979246] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
name	glutamine + H2O => glutamate + NH4+ (GLS) H2O + L-glutamine => L-glutamate + NH4(+)
output	[SimpleEntity:113552] L-Glu [mitochondrial matrix] [SimpleEntity:113561] NH4+ [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:212651] Transport of L-Glutamine (cytosol) to mitochondrial matrix [Homo sapiens] [Reaction:212642] L-Glutamine transport into neurons [Homo sapiens] [Reaction:212614] Glutamine transport from astrocytes [Homo sapiens] [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] [Homo sapiens] [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription [Homo sapiens] [Reaction:5632914] TP53 binds the GLS2 promoter [Homo sapiens]
releaseDate	2003-05-04
releaseStatus	UPDATED
reviewed	[InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359464] R-HSA-70609.5
summation	[Summation:178812] Mitochondrial glutaminase (GLS) catalyzes the hydrolysis of ...
(hasEvent)	[Pathway:210500] Glutamate Neurotransmitter Release Cycle [Homo sapiens] [Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens] [Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9930383] glutamine + H2O => glutamate + NH4+ (GLS) [Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) [Homo sapiens] [Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens] [Reaction:70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] [Homo sapiens] [Reaction:210444] L-Glutamate loading of synaptic vesicle [Homo sapiens] [BlackBoxEvent:212658] Tranport of L-Glutamate (mitochondrial matrix) to cytosol [Homo sapiens] [Reaction:508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] [Homo sapiens]
(replacementInstances)	[_Deleted:507863] Deletion of instance: 70612 [_Deleted:660244] Deletion of instance: 212613
(updatedInstance)	[_UpdateTracker:9790889] Update Tracker - [Reaction:70609] glutamine + H2O => glutamate + NH4+ [GLS] - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792367] Update Tracker - [Reaction:70609] glutamine + H2O => glutamate + NH4+ [GLS] - v22:[addLiteratureReference]
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