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Details on Person glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

Class:IdReaction:70606
_displayNameglutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
_doReleaseTRUE
_timestamp2024-11-08 15:23:03
catalystActivity[CatalystActivity:70605] glutamine synthetase activity of GLUL decamer [cytosol]
catalystActivityReference[CatalystActivityReference:9643796] glutamate-ammonia ligase activity of GLUL decamer [cytosol] Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9925789] RHEA:16170
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
[SimpleEntity:31633] NH4+ [cytosol]
internalReviewed[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
literatureReference[LiteratureReference:199781] Congenital glutamine deficiency with glutamine synthetase mutations
[LiteratureReference:507950] Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00
[InstanceEdit:507851] D'Eustachio, P, 2010-02-08
[InstanceEdit:507953] D'Eustachio, P, 2010-02-09
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:660239] D'Eustachio, P, 2010-04-30
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
[InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31
[InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
nameglutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29472] L-Gln [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360011] R-HSA-70606.5
structureModified[InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
summation[Summation:178810] Cytosolic glutamine synthetase (glutamate-ammonia ligase - G...
(hasEvent)[Pathway:210455] Astrocytic Glutamate-Glutamine Uptake And Metabolism [Homo sapiens]
[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(precedingEvent)[Reaction:212614] Glutamine transport from astrocytes [Homo sapiens]
[Reaction:893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Homo sapiens]
(replacementInstances)[_Deleted:660240] Deletion of instance: 210525
(updatedInstance)[_UpdateTracker:9791028] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v32:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9792267] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v22:[addLiteratureReference]
[_UpdateTracker:9928394] Update Tracker - [Reaction:70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - v91:[removeOutput]
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