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Details on Person glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)

Class:Id	Reaction:70600
_displayName	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
_doRelease	TRUE
_timestamp	2024-12-03 20:56:21
catalystActivity	[CatalystActivity:70584] L-glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643993] glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix] Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9925781] RHEA:15134 [DatabaseIdentifier:9925791] RHEA:11613
input	[SimpleEntity:113552] L-Glu [mitochondrial matrix] [DefinedSet:517495] NAD(P)+ [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix]
literatureReference	[LiteratureReference:507955] Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations [LiteratureReference:199756] Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme [LiteratureReference:507956] The structure of apo human glutamate dehydrogenase details subunit communication and allostery
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00 [InstanceEdit:507953] D'Eustachio, P, 2010-02-09 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:517497] D'Eustachio, P, 2010-02-18 [InstanceEdit:584171] D'Eustachio, P, 2010-04-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25 [InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03 [InstanceEdit:9930402] D'Eustachio, Peter, 2024-12-03
name	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) H2O + L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+) H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)
negativePrecedingEvent	[NegativePrecedingEvent:9930397] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
output	[SimpleEntity:113594] 2OG [mitochondrial matrix] [SimpleEntity:113561] NH4+ [mitochondrial matrix] [DefinedSet:517496] NAD(P)H [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Homo sapiens] [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [BlackBoxEvent:212651] Transport of L-Glutamine (cytosol) to mitochondrial matrix [Homo sapiens] [Reaction:212614] Glutamine transport from astrocytes [Homo sapiens] [BlackBoxEvent:5632924] TP53 stimulates GLS2 transcription [Homo sapiens]
regulatedBy	[PositiveRegulation:70601] Positive regulation by 'ADP [mitochondrial matrix]' [NegativeRegulation:70602] Negative regulation by 'GTP [mitochondrial matrix]'
releaseDate	2004-07-06
reverseReaction	[Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) [Homo sapiens] [Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360567] R-HSA-70600.7
summation	[Summation:178809] Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes th...
(hasEvent)	[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9930370] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) [NegativePrecedingEvent:9930382] Futile Cycle: glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) [NegativePrecedingEvent:9930386] Futile Cycle: glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
(reverseReaction)	[Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790703] Update Tracker - [Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] - v33:[addInput] [_UpdateTracker:9791052] Update Tracker - [Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText] [_UpdateTracker:9792292] Update Tracker - [Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] - v22:[addLiteratureReference] [_UpdateTracker:9928419] Update Tracker - [Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) - v91:[modifyText]
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No pathways have been reviewed or authored by glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (70600)