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Details on Person aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]

Class:IdReaction:70599
_displayNameaspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
_doReleaseTRUE
_timestamp2024-12-03 20:53:14
catalystActivity[CatalystActivity:70598] asparagine synthase (glutamine-hydrolyzing) activity of ASNS dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643819] asparagine synthase (glutamine-hydrolyzing) activity of ASNS dimer [cytosol] Expression of human asparagine synthetase in Escherichia coli
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9925769] RHEA:12229
input[SimpleEntity:29448] L-Asp [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29472] L-Gln [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
literatureReference[LiteratureReference:199780] Expression of human asparagine synthetase in Escherichia coli
modified[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00
[InstanceEdit:508032] D'Eustachio, P, 2010-02-10
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:584171] D'Eustachio, P, 2010-04-11
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24
[InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31
[InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
[InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
nameaspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate
negativePrecedingEvent[NegativePrecedingEvent:9930400] Futile Cycle: ASPG hydrolyses L-Asn to L-Asp
[NegativePrecedingEvent:9930395] Futile Cycle: SLC25A12,13 exchange L-Glu and L-Asp
[NegativePrecedingEvent:9930380] Futile Cycle: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
output[SimpleEntity:29642] L-Asn [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360335] R-HSA-70599.6
structureModified[InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24
summation[Summation:178479] Cytosolic asparagine synthase (ASNS) catalyzes the reaction ...
(hasEvent)[Pathway:8963693] Aspartate and asparagine metabolism [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9930377] Futile Cycle: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
[NegativePrecedingEvent:9930396] Futile Cycle: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
[NegativePrecedingEvent:9930398] Futile Cycle: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790405] Update Tracker - [Reaction:70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - v33:[addInput]
[_UpdateTracker:9790963] Update Tracker - [Reaction:70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - v32:[modifyText]
[_UpdateTracker:9792362] Update Tracker - [Reaction:70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - v22:[addLiteratureReference]
[_UpdateTracker:9928488] Update Tracker - [Reaction:70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - v91:[removeOutput]
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No pathways have been reviewed or authored by aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (70599)
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