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Details on Person GOT2 dimer transaminates L-Asp

Class:Id	Reaction:70596
_displayName	GOT2 dimer transaminates L-Asp
_doRelease	TRUE
_timestamp	2024-10-24 21:54:53
catalystActivity	[CatalystActivity:70595] L-aspartate:2-oxoglutarate transaminase activity of GOT2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643893] L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix] Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9856908] RHEA:21825
input	[SimpleEntity:113553] L-Asp [mitochondrial matrix] [SimpleEntity:113594] 2OG [mitochondrial matrix]
literatureReference	[LiteratureReference:199763] The primary structure of mitochondrial aspartate aminotransferase from human heart
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00 [InstanceEdit:507851] D'Eustachio, P, 2010-02-08 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9644732] Jassal, Bijay, 2019-04-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24
name	GOT2 dimer transaminates L-Asp 2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
output	[SimpleEntity:113587] OA [mitochondrial matrix] [SimpleEntity:113552] L-Glu [mitochondrial matrix]
releaseDate	2004-07-06
reverseReaction	[Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens] [Reaction:70596] GOT2 dimer transaminates L-Asp [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359642] R-HSA-70596.5
summation	[Summation:178478] Mitochondrial glutamate oxaloacetate transaminase 2 (asparta...
(hasEvent)	[Pathway:8963693] Aspartate and asparagine metabolism [Homo sapiens]
(reverseReaction)	[Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790851] Update Tracker - [Reaction:70596] GOT2 dimer deaminates L-Asp - v32:[modifyText] [_UpdateTracker:9792221] Update Tracker - [Reaction:70596] GOT2 dimer deaminates L-Asp - v22:[addLiteratureReference] [_UpdateTracker:9846835] Update Tracker - [Reaction:70596] GOT2 dimer deaminates L-Asp - v83:[modifyText]
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