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Details on Person alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)

Class:IdReaction:70589
_displayNamealpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
_doReleaseTRUE
_timestamp2024-12-03 20:53:11
catalystActivity[CatalystActivity:70584] L-glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9643993] glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix] Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
compartment[Compartment:5460] mitochondrial matrix
crossReference[DatabaseIdentifier:9925786] RHEA:15135
[DatabaseIdentifier:9925794] RHEA:11614
input[SimpleEntity:113594] 2OG [mitochondrial matrix]
[SimpleEntity:113561] NH4+ [mitochondrial matrix]
[DefinedSet:517496] NAD(P)H [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
literatureReference[LiteratureReference:507955] Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
[LiteratureReference:199756] Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme
[LiteratureReference:507956] The structure of apo human glutamate dehydrogenase details subunit communication and allostery
modified[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00
[InstanceEdit:507953] D'Eustachio, P, 2010-02-09
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:517497] D'Eustachio, P, 2010-02-18
[InstanceEdit:584171] D'Eustachio, P, 2010-04-11
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9925801] D'Eustachio, Peter, 2024-10-25
[InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
namealpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)
2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)
negativePrecedingEvent[NegativePrecedingEvent:9930393] Futile Cycle: GOT2 transaminates OA and L-Glu
[NegativePrecedingEvent:9930388] Futile Cycle: glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
[NegativePrecedingEvent:9930382] Futile Cycle: glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
[NegativePrecedingEvent:9930383] glutamine + H2O => glutamate + NH4+ (GLS)
output[SimpleEntity:113552] L-Glu [mitochondrial matrix]
[DefinedSet:517495] NAD(P)+ [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
regulatedBy[PositiveRegulation:70590] Positive regulation by 'ADP [mitochondrial matrix]'
[NegativeRegulation:70591] Negative regulation by 'GTP [mitochondrial matrix]'
regulationReference[RegulationReference:9641228] Positive regulation by 'ADP [mitochondrial matrix]' Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
[RegulationReference:9642935] Negative regulation by 'GTP [mitochondrial matrix]' Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
releaseDate2004-07-06
reverseReaction
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360938] R-HSA-70589.7
summation[Summation:178464] Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes th...
(hasEvent)[Pathway:8964539] Glutamate and glutamine metabolism [Homo sapiens]
(precedingEvent)[Reaction:508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] [Homo sapiens]
[NegativePrecedingEvent:9930379] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
[NegativePrecedingEvent:9930385] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
[NegativePrecedingEvent:9930397] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
(reverseReaction)[Reaction:70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790718] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v33:[addOutput]
[_UpdateTracker:9790862] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText]
[_UpdateTracker:9792272] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v22:[addLiteratureReference]
[_UpdateTracker:9928534] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - v91:[modifyText]
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