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Details on Person oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]

Class:IdReaction:70581
_displayNameoxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
_doReleaseTRUE
_timestamp2024-12-03 20:53:29
catalystActivity[CatalystActivity:70580] L-aspartate:2-oxoglutarate transaminase activity of PXLP-K259-GOT1 dimer [cytosol]
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9856887] RHEA:21826
input[SimpleEntity:29404] L-Glu [cytosol]
[SimpleEntity:76213] OA [cytosol]
literatureReference[LiteratureReference:199740] The amino acid sequence of cytosolic aspartate aminotransferase from human liver
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00
[InstanceEdit:452030] D'Eustachio, P, 2010-01-14
[InstanceEdit:507851] D'Eustachio, P, 2010-02-08
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9925772] D'Eustachio, Peter, 2024-10-24
[InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
nameoxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate
negativePrecedingEvent[NegativePrecedingEvent:9930390] Futile Cycle: PXLP-K259-GOT1 transaminates 2-OG and L-Asp
[NegativePrecedingEvent:9930377] Futile Cycle: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]
output[SimpleEntity:29406] 2OG [cytosol]
[SimpleEntity:29448] L-Asp [cytosol]
precedingEvent
releaseDate2004-07-06
reverseReaction
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359756] R-HSA-70581.5
summation[Summation:179018] Cytosolic aspartate aminotransferase (glutamate oxaloacetate...
(hasEvent)[Pathway:8963693] Aspartate and asparagine metabolism [Homo sapiens]
(precedingEvent)[Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Homo sapiens]
[Reaction:6787757] PXLP-K333-GADL1 decarboxylates acidic AAs [Homo sapiens]
[NegativePrecedingEvent:9930374] Futile Cycle: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
[NegativePrecedingEvent:9930380] Futile Cycle: oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
(reverseReaction)[Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791222] Update Tracker - [Reaction:70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - v32:[modifyText]
[_UpdateTracker:9792205] Update Tracker - [Reaction:70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - v22:[addLiteratureReference]
[_UpdateTracker:9846942] Update Tracker - [Reaction:70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - v83:[modifyText]
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