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Details on Person ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA

Class:Id	Reaction:70577
_displayName	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
_doRelease	TRUE
_timestamp	2026-05-07 22:30:40
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70576] argininosuccinate synthase activity of ASS1 tetramer:NMRAL1 dimer:NADPH [cytosol]
catalystActivityReference	[CatalystActivityReference:9643595] argininosuccinate synthase activity of ASS1 tetramer:NMRAL1 dimer:NADPH [cytosol] Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9988061] RHEA:10933
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29448] L-Asp [cytosol] [SimpleEntity:29968] L-Cit [cytosol]
internalReviewed	[InstanceEdit:9988070] D'Eustachio, Peter, 2026-05-01 [InstanceEdit:9988524] D'Eustachio, Peter, 2026-05-07
literatureReference	[LiteratureReference:451985] Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene [LiteratureReference:451992] Structure of human argininosuccinate synthetase [LiteratureReference:74567] Isolation and characterization of argininosuccinate synthetase from human liver [LiteratureReference:6810885] Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein [LiteratureReference:6810872] An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability
modified	[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:452030] D'Eustachio, P, 2010-01-14 [InstanceEdit:1080818] D'Eustachio, P, 2010-11-27 [InstanceEdit:6810882] Jassal, Bijay, 2015-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01 [InstanceEdit:9988069] D'Eustachio, Peter, 2026-05-01 [InstanceEdit:9988525] D'Eustachio, Peter, 2026-05-07 [InstanceEdit:9988528] D'Eustachio, Peter, 2026-05-07
name	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA L-citrulline + L-aspartate + ATP => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
output	[SimpleEntity:34575] ARSUA [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Homo sapiens] [Reaction:70569] arginine + H2O => ornithine + urea [ARG1] [Homo sapiens] [Reaction:70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate [Homo sapiens] [Reaction:70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] [Homo sapiens] [Reaction:5693783] NAALADases hydrolyse NAAG [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewed	[InstanceEdit:9988529] Hill, David P, 2026-05-07
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:452018] D'Eustachio, P, 2010-01-14 [InstanceEdit:6810886] Jassal, Bijay, 2015-11-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360984] R-HSA-70577.5
structureModified	[InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
summation	[Summation:178493] Cytosolic argininosuccinate synthase (ASS1 tetramer) catalyz...
(hasEvent)	[Pathway:70635] Urea cycle [Homo sapiens]
(inferredFrom)	[Reaction:1113202] ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate [Oryza sativa]
(normalReaction)	[FailedReaction:9956517] ASS1 variants don't synthesize arginosuccinate [Homo sapiens]
(orthologousEvent)	[Reaction:1113202] ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate [Oryza sativa]
(precedingEvent)	[Reaction:70573] argininosuccinate <=> fumarate + arginine [Homo sapiens] [Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783430] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v56:[addLiteratureReference, modifyText] [_UpdateTracker:9789598] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v37:[modifyText] [_UpdateTracker:9791236] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v32:[add_removeLiteratureReference, modifyText]
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