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Details on Person argininosuccinate <=> fumarate + arginine

Class:Id	Reaction:70573
_displayName	argininosuccinate <=> fumarate + arginine
_doRelease	TRUE
_timestamp	2026-05-01 21:31:07
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70572] argininosuccinate lyase activity of ASL tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643560] argininosuccinate lyase activity of ASL tetramer [cytosol] Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9988063] RHEA:24021
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:34575] ARSUA [cytosol]
literatureReference	[LiteratureReference:452044] Human argininosuccinate lyase: a structural basis for intragenic complementation [LiteratureReference:452031] Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:452030] D'Eustachio, P, 2010-01-14 [InstanceEdit:1080818] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
name	argininosuccinate <=> fumarate + arginine 2-(N(omega)-L-arginino)succinate => fumarate + L-arginine
output	[SimpleEntity:29468] L-Arg [cytosol] [SimpleEntity:29586] FUMA [cytosol]
precedingEvent	[Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Homo sapiens] [Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Homo sapiens] [Reaction:70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:452018] D'Eustachio, P, 2010-01-14
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359526] R-HSA-70573.4
summation	[Summation:178476] Cytosolic argininosuccinate lyase (ASL) catalyzes the revers...
(hasEvent)	[Pathway:70635] Urea cycle [Homo sapiens]
(normalReaction)	[FailedReaction:9956524] ASL variants don't synthesize fumarate and arginine [Homo sapiens]
(precedingEvent)	[Reaction:70569] arginine + H2O => ornithine + urea [ARG1] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791231] Update Tracker - [Reaction:70573] argininosuccinate <=> fumarate + arginine - v32:[add_removeLiteratureReference, modifyText]
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