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Details on Person arginine + H2O => ornithine + urea [ARG1]

Class:Id	Reaction:70569
_displayName	arginine + H2O => ornithine + urea [ARG1]
_doRelease	TRUE
_timestamp	2026-05-07 16:51:28
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70568] arginase activity of ARG1 trimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643696] arginase activity of ARG1 trimer [cytosol] Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9988057] RHEA:20570
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:29468] L-Arg [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:451999] Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response [LiteratureReference:452019] Molecular basis of phenotypic variation in patients with argininemia
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:452030] D'Eustachio, P, 2010-01-14 [InstanceEdit:1080818] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01 [InstanceEdit:9988428] D'Eustachio, Peter, 2026-05-07
name	arginine + H2O => ornithine + urea [ARG1] L-arginine + H2O => urea + L-ornithine
output	[SimpleEntity:29498] L-Orn [cytosol] [SimpleEntity:29514] Urea [cytosol]
precedingEvent	[Reaction:70573] argininosuccinate <=> fumarate + arginine [Homo sapiens] [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Homo sapiens] [BlackBoxEvent:9959871] ARG1 gene expression [Homo sapiens] [Reaction:9959857] TP53 binds ARG1 gene [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:452018] D'Eustachio, P, 2010-01-14
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360068] R-HSA-70569.4
summation	[Summation:178475] Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis ...
(hasEvent)	[Pathway:70635] Urea cycle [Homo sapiens]
(normalReaction)	[FailedReaction:9956512] ARG1 variants don't synthesize urea and ornithine [Homo sapiens]
(precedingEvent)	[Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790899] Update Tracker - [Reaction:70569] arginine + H2O => ornithine + urea [ARG1] - v32:[addInput, add_removeLiteratureReference, modifyText]
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