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Details on Person carbamoyl phosphate + ornithine => citrulline + orthophosphate

Class:Id	Reaction:70560
_displayName	carbamoyl phosphate + ornithine => citrulline + orthophosphate
_doRelease	TRUE
_timestamp	2026-05-07 22:30:57
authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70559] ornithine carbamoyltransferase activity of OTC trimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643158] ornithine carbamoyltransferase activity of OTC trimer [mitochondrial matrix] Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9988064] RHEA:19514
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
input	[SimpleEntity:29676] CAP [mitochondrial matrix] [SimpleEntity:113585] L-Orn [mitochondrial matrix]
internalReviewed	[InstanceEdit:9988070] D'Eustachio, Peter, 2026-05-01 [InstanceEdit:9988524] D'Eustachio, Peter, 2026-05-07
literatureReference	[LiteratureReference:71418] Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase [LiteratureReference:452023] Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:452030] D'Eustachio, P, 2010-01-14 [InstanceEdit:1080818] D'Eustachio, P, 2010-11-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9956541] Rothfels, Karen, 2025-06-12 [InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01 [InstanceEdit:9988069] D'Eustachio, Peter, 2026-05-01 [InstanceEdit:9988525] D'Eustachio, Peter, 2026-05-07 [InstanceEdit:9988528] D'Eustachio, Peter, 2026-05-07
name	carbamoyl phosphate + ornithine => citrulline + orthophosphate carbamoyl phosphate + L-ornithine => L-citrulline + phosphate + H(+)
output	[SimpleEntity:113567] L-Cit [mitochondrial matrix] [SimpleEntity:113548] Pi [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:70555] 2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] [Homo sapiens] [Reaction:70542] glutamate + acetyl CoA => N-acetyl glutamate + CoA [Homo sapiens] [Reaction:73591] conversion of 3-ureidopropionate to beta-alanine [Homo sapiens] [Reaction:9955518] SIRT5 desuccinylates CPS1 [Homo sapiens] [Reaction:9955504] SIRT5 deglutarylates CPS1 [Homo sapiens] [BlackBoxEvent:9959874] CPS1 gene expression [Homo sapiens] [Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Homo sapiens] [Reaction:70569] arginine + H2O => ornithine + urea [ARG1] [Homo sapiens] [Reaction:70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate [Homo sapiens] [Reaction:70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] [Homo sapiens] [Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS [Homo sapiens] [Reaction:508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [BlackBoxEvent:9956502] OTC precursor is targeted to the mitochondrial matrix and processed [Homo sapiens] [BlackBoxEvent:9959881] OTC gene expression [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9988529] Hill, David P, 2026-05-07
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:452018] D'Eustachio, P, 2010-01-14
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359764] R-HSA-70560.5
structureModified	[InstanceEdit:9988059] D'Eustachio, Peter, 2026-05-01
summation	[Summation:178528] Mitochondrial ornithine transcarbamoylase (OTC) catalyzes th...
(hasEvent)	[Pathway:70635] Urea cycle [Homo sapiens]
(normalReaction)	[FailedReaction:9956527] OTC variants don't synthesize L-citrulline [Homo sapiens]
(precedingEvent)	[Reaction:70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791127] Update Tracker - [Reaction:70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - v32:[addLiteratureReference, modifyText]
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