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Details on Person PXLP-K314-GPT transaminates L-Ala to form PYR

Class:IdReaction:70523
_displayNamePXLP-K314-GPT transaminates L-Ala to form PYR
_doReleaseTRUE
_timestamp2024-12-03 20:52:51
catalystActivity[CatalystActivity:70522] L-alanine:2-oxoglutarate aminotransferase activity of PXLP-K314-GPT dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643950] L-alanine:2-oxoglutarate aminotransferase activity of GPT dimer [cytosol] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9861843] RHEA:19454
input[SimpleEntity:29432] L-Ala [cytosol]
[SimpleEntity:29406] 2OG [cytosol]
literatureReference[LiteratureReference:507765] Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods
[LiteratureReference:199767] Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites.
[LiteratureReference:507751] cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:199761] D'Eustachio, P, 2007-07-11 22:14:00
[InstanceEdit:507750] D'Eustachio, P, 2010-02-08
[InstanceEdit:517476] D'Eustachio, P, 2010-02-18
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9644835] Jassal, Bijay, 2019-04-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9861887] Stephan, Ralf, 2024-02-21
[InstanceEdit:9862190] Stephan, Ralf, 2024-02-23
[InstanceEdit:9930378] D'Eustachio, Peter, 2024-12-03
namePXLP-K314-GPT transaminates L-Ala to form PYR
alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]
negativePrecedingEvent[NegativePrecedingEvent:9930399] Futile Cycle: PXLP-K314-GPT transaminates PYR to form L-Ala
output[SimpleEntity:29398] PYR [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
releaseDate2004-07-06
reverseReaction
reviewed[InstanceEdit:9862191] Hill, David P, 2024-02-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:362032] R-HSA-70523.6
summation[Summation:178457] Cytosolic glutamic-pyruvate transaminase (alanine aminotrans...
(hasEvent)[Pathway:70268] Pyruvate metabolism [Homo sapiens]
[Pathway:8964540] Alanine metabolism [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9930369] Futile Cycle: PXLP-K314-GPT transaminates L-Ala to form PYR
[Reaction:71849] LDH tetramer reduces PYR to LACT [Homo sapiens]
[Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens]
[Reaction:9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Homo sapiens]
[Reaction:9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Homo sapiens]
(replacementInstances)[_Deleted:507778] Deletion of instance: 70525
(reverseReaction)[Reaction:70524] PXLP-K314-GPT transaminates PYR to form L-Ala [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790971] Update Tracker - [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR - v32:[addLiteratureReference, modifyText]
[_UpdateTracker:9792352] Update Tracker - [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR - v22:[addLiteratureReference]
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