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Details on Person LDH tetramer oxidises LACT to PYR
Class:Id Reaction:70510 _displayName LDH tetramer oxidises LACT to PYR _doRelease TRUE _timestamp 2024-04-24 07:26:30 catalystActivity [CatalystActivity:70509] L-lactate dehydrogenase (NAD+) activity of LDH tetramer [cytosol] catalystActivityReference [CatalystActivityReference:9643670] L-lactate dehydrogenase activity of LDH tetramer [cytosol] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli compartment [Compartment:70101] cytosol crossReference [DatabaseIdentifier:9861806] RHEA:23445 input [SimpleEntity:29708] LACT [cytosol] [SimpleEntity:29360] NAD+ [cytosol] literatureReference [LiteratureReference:6807598] Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA) [LiteratureReference:6807523] Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli [LiteratureReference:6808368] Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence [LiteratureReference:179539] Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase [LiteratureReference:179533] The cDNA and protein sequences of human lactate dehydrogenase B [LiteratureReference:179524] Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4 [LiteratureReference:9861797] The Biochemical and Clinical Perspectives of Lactate Dehydrogenase: An Enzyme of Active Metabolism [LiteratureReference:9861717] Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis modified [InstanceEdit:113752] Schmidt, EE, 2004-06-21 10:53:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:179525] D'Eustachio, P, 2006-05-05 20:50:49 [InstanceEdit:450855] D'Eustachio, P, 2009-12-18 [InstanceEdit:6807522] D'Eustachio, Peter, 2015-11-02 [InstanceEdit:6808363] D'Eustachio, Peter, 2015-11-04 [InstanceEdit:6809180] D'Eustachio, Peter, 2015-11-09 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9012031] Jassal, Bijay, 2017-07-10 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861803] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862185] Stephan, Ralf, 2024-02-23 [InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 name LDH tetramer oxidises LACT to PYR negativePrecedingEvent [NegativePrecedingEvent:9908917] Futile Cycle: LDH tetramer reduces PYR to LACT output [SimpleEntity:29398] PYR [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol] regulatedBy [NegativeRegulation:9861807] Negative regulation by 'PolyUb-LDHA [cytosol]' regulationReference [RegulationReference:9861794] Negative regulation by 'PolyUb-LDHA [cytosol]' Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis releaseDate 2004-07-06 reverseReaction
reviewed [InstanceEdit:6809181] Jassal, Bijay, 2015-11-09 [InstanceEdit:9862191] Hill, David P, 2024-02-23 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:450856] D'Eustachio, P, 2009-12-18 [InstanceEdit:6809179] D'Eustachio, Peter, 2015-11-09 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:359791] R-HSA-70510.8 summation [Summation:70511] Cytosolic lactate dehydrogenase (LDH) catalyzes the freely r... (hasEvent) [Pathway:70268] Pyruvate metabolism [Homo sapiens] (precedingEvent) [NegativePrecedingEvent:9908919] Futile Cycle: LDH tetramer oxidises LACT to PYR [Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Homo sapiens] [Reaction:9861595] Cytosolic H2O2 decarboxylates PYR to acetate [Homo sapiens] (reverseReaction) [Reaction:71849] LDH tetramer reduces PYR to LACT [Homo sapiens] (updatedInstance) [_UpdateTracker:9784000] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v55:[addLiteratureReference, modifyText] [_UpdateTracker:9791083] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v32:[modifyText] [_UpdateTracker:9864273] Update Tracker - [Reaction:70510] LDH tetramer oxidises LACT to PYR - v88:[addLiteratureReference, addRegulator, modifyText]
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