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Details on Person PC carboxylates PYR to OA

Class:Id	Reaction:70501
_displayName	PC carboxylates PYR to OA
_doRelease	TRUE
_timestamp	2025-01-25 19:09:18
catalystActivity	[CatalystActivity:70500] pyruvate carboxylase activity of PC tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9815324] pyruvate carboxylase activity of pyruvate carboxylase holoenzyme [mitochondrial matrix] Expression and characterization of a human pyruvate carboxylase variant by retroviral gene transfer
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9861808] RHEA:20845
goBiologicalProcess	[GO_BiologicalProcess:15002] gluconeogenesis
input	[SimpleEntity:113593] ATP [mitochondrial matrix] [SimpleEntity:113557] PYR [mitochondrial matrix] [SimpleEntity:29896] HCO3- [mitochondrial matrix]
literatureReference	[LiteratureReference:198433] Expression and characterization of a human pyruvate carboxylase variant by retroviral gene transfer [LiteratureReference:198464] Structure, function and regulation of pyruvate carboxylase [LiteratureReference:9815323] Structure, mechanism and regulation of pyruvate carboxylase [LiteratureReference:9861904] Molecular characterization of pyruvate carboxylase deficiency in two consanguineous families [LiteratureReference:9861902] CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [LiteratureReference:9861858] Purification and properties of human liver pyruvate carboxylase [LiteratureReference:9861869] Roles of pyruvate carboxylase in human diseases: from diabetes to cancers and infection [LiteratureReference:9861884] Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis
modified	[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:179525] D'Eustachio, P, 2006-05-05 20:50:49 [InstanceEdit:179525] D'Eustachio, P, 2006-05-05 20:50:49 [InstanceEdit:179525] D'Eustachio, P, 2006-05-05 20:50:49 [InstanceEdit:179525] D'Eustachio, P, 2006-05-05 20:50:49 [InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01 [InstanceEdit:372822] D'Eustachio, P, 2008-07-03 22:07:04 [InstanceEdit:372849] D'Eustachio, P, 2008-07-07 20:55:07 [InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07 [InstanceEdit:517476] D'Eustachio, P, 2010-02-18 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9815308] D'Eustachio, Peter, 2022-08-16 [InstanceEdit:9815705] D'Eustachio, Peter, 2022-08-25 [InstanceEdit:9815858] D'Eustachio, Peter, 2022-08-29 [InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861887] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9936712] D'Eustachio, Peter, 2025-01-25
name	PC carboxylates PYR to OA PC catalyzes the carboxylation of PYR to form OA ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate
output	[SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113548] Pi [mitochondrial matrix] [SimpleEntity:113587] OA [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix [Homo sapiens] [Reaction:71670] Pyruvate kinase dephosphorylates PEP to PYR [Homo sapiens] [Reaction:70510] LDH tetramer oxidises LACT to PYR [Homo sapiens] [Reaction:70523] PXLP-K314-GPT transaminates L-Ala to form PYR [Homo sapiens] [Reaction:9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space [Homo sapiens] [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:70501] PC carboxylates PYR to OA [Homo sapiens] [Reaction:9012268] ME2 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens] [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR [Homo sapiens] [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens] [Reaction:9861667] DLAT trimer transfers acetyl to CoA [Homo sapiens] [Reaction:9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT [Homo sapiens] [Reaction:204169] PDP1,2 dephosphorylate p-lipo-PDH [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[Requirement:71425] Requirement by 'Ac-CoA [mitochondrial matrix]' [NegativeRegulation:9861840] Negative regulation by '2OG [mitochondrial matrix]' [NegativeRegulation:9861871] Negative regulation by 'L-Glu [mitochondrial matrix]' [NegativeRegulation:9861847] Negative regulation by 'MAL [mitochondrial matrix]'
regulationReference	[RegulationReference:9815314] Requirement by 'Ac-CoA [mitochondrial matrix]' Structure, mechanism and regulation of pyruvate carboxylase [RegulationReference:9861868] Negative regulation by '2OG [mitochondrial matrix]' Purification and properties of human liver pyruvate carboxylase [RegulationReference:9861854] Negative regulation by 'L-Glu [mitochondrial matrix]' Purification and properties of human liver pyruvate carboxylase [RegulationReference:9861885] Negative regulation by 'MAL [mitochondrial matrix]' Purification and properties of human liver pyruvate carboxylase
releaseDate	2004-07-06
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12 [InstanceEdit:9815859] Hill, David P, 2022-08-29 [InstanceEdit:9862191] Hill, David P, 2024-02-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361020] R-HSA-70501.9
structureModified	[InstanceEdit:9861887] Stephan, Ralf, 2024-02-21
summation	[Summation:71426] Mitochondrial pyruvate carboxylase (PC) catalyzes the irreve...
(hasEvent)	[Pathway:70263] Gluconeogenesis [Homo sapiens] [Pathway:70268] Pyruvate metabolism [Homo sapiens]
(precedingEvent)	[Reaction:70613] GOT2 transaminates OA and L-Glu [Homo sapiens] [Reaction:70975] CS acetylates OA to citrate [Homo sapiens] [Reaction:71783] MDH2 dimer reduces OA to MAL [Homo sapiens] [Reaction:372819] PCK2 phosphorylates OA to yield PEP [Homo sapiens] [Reaction:9012016] FAHD1 dimer hydrolyses OA to PYR [Homo sapiens] [Reaction:9863545] Clone of MDH2 dimer reduces OA to MAL [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791657] Update Tracker - [Reaction:70501] Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate - v28:[add_removeRegulator] [_UpdateTracker:9791756] Update Tracker - [Reaction:70501] Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate - v26:[add_removeInput, modifyText] [_UpdateTracker:9792214] Update Tracker - [Reaction:70501] Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate - v22:[addLiteratureReference, modifyText] [_UpdateTracker:9846891] Update Tracker - [Reaction:70501] PC catalyzes the carboxylation of PYR to form OA - v83:[modifyText] [_UpdateTracker:9846984] Update Tracker - [Reaction:70501] PC catalyzes the carboxylation of PYR to form OA - v82:[addLiteratureReference, addOutput, add_removeInput, modifyText] [_UpdateTracker:9864206] Update Tracker - [Reaction:70501] PC carboxylates PYR to OA - v88:[addLiteratureReference, addRegulator, modifyText]
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