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Details on Person Enolase dimers (ENO1,2,3) convert PEP to 2PG

Class:IdReaction:70494
_displayNameEnolase dimers (ENO1,2,3) convert PEP to 2PG
_doReleaseTRUE
_timestamp2025-01-01 11:04:24
catalystActivity[CatalystActivity:71439] phosphopyruvate hydratase activity of enolase dimer [cytosol]
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9933514] RHEA:10166
input[SimpleEntity:29492] PEP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
literatureReference[LiteratureReference:141510] Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis
[LiteratureReference:141517] Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
[LiteratureReference:141548] Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:179499] D'Eustachio, P, 2006-05-04 21:45:03
[InstanceEdit:179502] D'Eustachio, P, 2006-05-04 21:54:10
[InstanceEdit:198551] D'Eustachio, P, 2007-06-22 16:17:09
[InstanceEdit:372822] D'Eustachio, P, 2008-07-03 22:07:04
[InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9815667] D'Eustachio, Peter, 2022-08-25
[InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
nameEnolase dimers (ENO1,2,3) convert PEP to 2PG
H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate
output[SimpleEntity:30485] 2PG [cytosol]
precedingEvent
releaseDate2004-07-06
reverseReaction
reviewed[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
[InstanceEdit:9815859] Hill, David P, 2022-08-29
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361370] R-HSA-70494.5
summation[Summation:179498] Cytosolic enolase dimers catalyze the reversible reaction of...
(hasEvent)[Pathway:70263] Gluconeogenesis [Homo sapiens]
(precedingEvent)[Reaction:71445] PGAM dimers isomerise 2PG to 3PG [Homo sapiens]
(reverseReaction)[Reaction:71660] Enolase dimers dehydrates 2PG [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791732] Update Tracker - [Reaction:70494] Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate - v26:[modifyText]
[_UpdateTracker:9846658] Update Tracker - [Reaction:70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG - v84:[modifyText]
[_UpdateTracker:9846910] Update Tracker - [Reaction:70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG - v83:[modifyText]
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