Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person GPI dimer isomerizes G6P

Class:IdReaction:70471
_displayNameGPI dimer isomerizes G6P
_doReleaseTRUE
_timestamp2025-01-01 11:05:30
catalystActivity[CatalystActivity:70470] glucose-6-phosphate isomerase activity of GPI dimer [cytosol]
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9933532] RHEA:11817
input[SimpleEntity:30537] G6P [cytosol]
literatureReference[Book:71618] The Enzymes, 3rd ed Boyer, PD Phosphofructokinase 0121227022
[Book:70473] The Enzymes, 3rd ed Boyer, PD Aldose-ketose isomerases 0121227022
[LiteratureReference:450657] The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia
[LiteratureReference:141483] Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.
[LiteratureReference:141528] The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia
modified[InstanceEdit:70351] 2003-03-01 00:00:00
[InstanceEdit:141606] D'Eustachio, P, 2004-09-21 16:32:25
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01
[InstanceEdit:450111] D'Eustachio, P, 2009-12-11
[InstanceEdit:450111] D'Eustachio, P, 2009-12-11
[InstanceEdit:450111] D'Eustachio, P, 2009-12-11
[InstanceEdit:450111] D'Eustachio, P, 2009-12-11
[InstanceEdit:450636] D'Eustachio, P, 2009-12-16
[InstanceEdit:450684] D'Eustachio, P, 2009-12-16
[InstanceEdit:500020] May, B, 2010-01-30
[InstanceEdit:622423] D'Eustachio, P, 2010-04-23
[InstanceEdit:6784256] Jassal, Bijay, 2015-06-19
[InstanceEdit:6786209] Jassal, Bijay, 2015-07-06
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9793234] D'Eustachio, Peter, 2022-06-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
nameGPI dimer isomerizes G6P
alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate
Glucose 6-phosphate is isomerized to form fructose-6-phosphate
output[SimpleEntity:29512] Fru(6)P [cytosol]
precedingEvent
releaseDate2004-07-06
reverseReaction
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:362091] R-HSA-70471.6
summation[Summation:70472] Cytosolic phosphoglucose isomerase catalyzes the reversible ...
(hasEvent)[Pathway:70171] Glycolysis [Homo sapiens]
(precedingEvent)[Reaction:70467] PFK tetramer phosphorylates Fru(6)P [Homo sapiens]
[Reaction:71802] PFKFKB dimer phosphorylates Fru(6)P [Homo sapiens]
[Reaction:163751] D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate [Homo sapiens]
[Reaction:163764] D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate [Homo sapiens]
[Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P [Homo sapiens]
[Reaction:532549] MPI isomerises Fru6P to Man6P [Homo sapiens]
(replacementInstances)[_Deleted:450675] Deletion of instance: 70112
(reverseReaction)[Reaction:70475] GPI dimer isomerizes Fru(6)P to G6P [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791167] Update Tracker - [Reaction:70471] alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate - v32:[addLiteratureReference, modifyText]
[_UpdateTracker:9792339] Update Tracker - [Reaction:70471] alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate - v22:[addLiteratureReference]
[Change default viewing format]
No pathways have been reviewed or authored by GPI dimer isomerizes G6P (70471)
Follow Reactome