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Details on Person PFK tetramer phosphorylates Fru(6)P

Class:Id	Reaction:70467
_displayName	PFK tetramer phosphorylates Fru(6)P
_doRelease	TRUE
_timestamp	2025-01-01 11:06:24
catalystActivity	[CatalystActivity:70466] 6-phosphofructokinase activity of PFK tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644014] 6-phosphofructokinase activity of PFK tetramer [cytosol] Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9933535] RHEA:16110
input	[SimpleEntity:29512] Fru(6)P [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:71622] Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet [LiteratureReference:141464] Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency [LiteratureReference:141470] Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system [LiteratureReference:141529] Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system [LiteratureReference:70305] Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII
modified	[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:141577] D'Eustachio, P, 2004-09-21 15:32:02 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:179513] D'Eustachio, P, 2006-05-05 18:17:28 [InstanceEdit:211334] D'Eustachio, P, 2008-01-31 21:04:16 [InstanceEdit:450636] D'Eustachio, P, 2009-12-16 [InstanceEdit:450684] D'Eustachio, P, 2009-12-16 [InstanceEdit:6814311] Jassal, Bijay, 2015-11-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9816320] D'Eustachio, Peter, 2022-09-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
name	PFK tetramer phosphorylates Fru(6)P D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP
output	[SimpleEntity:30014] F1,6PP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:70471] GPI dimer isomerizes G6P [Homo sapiens] [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P [Homo sapiens] [Reaction:5696021] ADPGK:Mg2+ phosphorylates Glc to G6P [Homo sapiens] [Reaction:6799604] GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P [Homo sapiens] [Reaction:6803789] AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA [Homo sapiens] [Reaction:449715] GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P [Homo sapiens]
regulatedBy	[PositiveRegulation:71504] Positive regulation by 'AMP [cytosol]' [PositiveRegulation:71505] Positive regulation by 'ADP [cytosol]' [PositiveRegulation:71506] Positive regulation by 'D-Fructose 2,6-bisphosphate [cytosol]' [NegativeRegulation:71507] Negative regulation by 'ATP [cytosol]' [NegativeRegulation:71508] Negative regulation by 'CIT [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359184] R-HSA-70467.8
summation	[Summation:71462] Cytosolic phosphofructokinase 1 catalyzes the reaction of fr...
(hasEvent)	[Pathway:70171] Glycolysis [Homo sapiens]
(precedingEvent)	[Reaction:71496] Aldolase tetramer cleaves F1,6PP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791141] Update Tracker - [Reaction:70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9846895] Update Tracker - [Reaction:70467] D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP - v83:[addOutput] [_UpdateTracker:9971824] Update Tracker - [Reaction:70467] PFK tetramer phosphorylates Fru(6)P - v95:[modifyText]
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