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Details on Person GADPH tetramer dehydrogenates GA3P

Class:Id	Reaction:70449
_displayName	GADPH tetramer dehydrogenates GA3P
_doRelease	TRUE
_timestamp	2025-01-01 11:04:49
catalystActivity	[CatalystActivity:70448] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramers [cytosol]
catalystActivityReference	[CatalystActivityReference:9644037] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramers [cytosol] Glyceraldehyde-3-phosphate dehydrogenase from human tissues
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9933525] RHEA:10301
input	[SimpleEntity:29578] GA3P [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
literatureReference	[LiteratureReference:70430] Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations [LiteratureReference:71644] Crystalline D-glyceraldehyde-3-phosphate dehydrogenase from rabbit muscle [LiteratureReference:70436] Isozymes of glyceraldehyde 3-phosphate dehydrogenase in man and other mammals [LiteratureReference:141459] Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene [LiteratureReference:70433] Glyceraldehyde-3-phosphate dehydrogenase from human tissues [LiteratureReference:70439] Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells [LiteratureReference:71647] The prosthetic group of crystalline d-glyceraldehyde-3-phosphate dehydrogenase
modified	[InstanceEdit:113752] Schmidt, EE, 2004-06-21 10:53:00 [InstanceEdit:141600] D'Eustachio, P, 2004-09-21 16:31:24 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:198534] D'Eustachio, P, 2007-06-22 15:53:40 [InstanceEdit:450636] D'Eustachio, P, 2009-12-16 [InstanceEdit:450684] D'Eustachio, P, 2009-12-16 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
name	GADPH tetramer dehydrogenates GA3P D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ Glyceraldehyde 3 phosphate, NAD+, and orthophosphate react to form 1,3 bisphosphoglycerate and NADH + H+
output	[SimpleEntity:29800] 1,3BPG [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:70454] TPI1 dimer isomerizes DHAP to GA3P [Homo sapiens] [Reaction:71496] Aldolase tetramer cleaves F1,6PP [Homo sapiens] [Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP [Homo sapiens] [Reaction:70349] DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate [Homo sapiens] [Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:70482] GAPDH tetramers reduce 1,3BPG to GA3P [Homo sapiens] [Reaction:70449] GADPH tetramer dehydrogenates GA3P [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450685] D'Eustachio, P, 2009-12-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358341] R-HSA-70449.5
summation	[Summation:71510] Cytosolic glyceraldehyde 3-phosphate dehydrogenase catalyzes...
(hasEvent)	[Pathway:70171] Glycolysis [Homo sapiens]
(precedingEvent)	[Reaction:71850] PGK complexes dephosphorylate 1,3BPG [Homo sapiens] [Reaction:6798335] BPGM dimer isomerises 1,3BPG to 2,3BPG [Homo sapiens] [Reaction:9638125] PGM1:Mg2+ isomerises G1P to G6P [Homo sapiens] [Reaction:9856871] MDH1 reduces OA [Homo sapiens]
(replacementInstances)	[_Deleted:450676] Deletion of instance: 70108
(reverseReaction)	[Reaction:70482] GAPDH tetramers reduce 1,3BPG to GA3P [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791042] Update Tracker - [Reaction:70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792213] Update Tracker - [Reaction:70449] D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ - v22:[addLiteratureReference, modifyText]
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