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Details on Person HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P
Class:Id Reaction:70420 _displayName HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P _doRelease TRUE _timestamp 2025-01-01 11:05:53 catalystActivity [CatalystActivity:70419] glucokinase activity of glucokinase and hexokinases [cytosol] compartment [Compartment:70101] cytosol crossReference [DatabaseIdentifier:9933515] RHEA:17826 input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:70113] Glc [cytosol] literatureReference [LiteratureReference:199694] The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate [LiteratureReference:9820637] Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1 [LiteratureReference:199692] Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity [LiteratureReference:9828521] Hepatic HKDC1 Expression Contributes to Liver Metabolism [LiteratureReference:199700] Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes. [LiteratureReference:199710] Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants. [LiteratureReference:391483] Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs [LiteratureReference:264743] GLUT2 in pancreatic and extra-pancreatic gluco-detection (review) [LiteratureReference:9828532] Hexokinase domain-containing protein-1 in metabolic diseases and beyond modified [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:156746] D'Eustachio, P, 2004-12-09 17:18:23 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01 [InstanceEdit:199720] D'Eustachio, P, 2007-07-11 20:28:53 [InstanceEdit:390388] May, B, 2009-02-06 03:03:21 [InstanceEdit:391484] D'Eustachio, P, 2009-02-22 18:57:28 [InstanceEdit:450085] D'Eustachio, P, 2009-12-11 [InstanceEdit:499987] May, B, 2010-01-29 [InstanceEdit:500016] May, B, 2010-01-30 [InstanceEdit:622328] D'Eustachio, P, 2010-04-22 [InstanceEdit:5621911] Jassal, Bijay, 2014-09-05 [InstanceEdit:5621922] Jassal, Bijay, 2014-09-05 [InstanceEdit:5661113] D'Eustachio, Peter, 2015-01-08 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981584] D'Eustachio, Peter, 2017-03-10 [InstanceEdit:9674668] D'Eustachio, Peter, 2020-01-22 [InstanceEdit:9675020] Murillo, Julieth, 2020-01-29 [InstanceEdit:9820633] D'Eustachio, Peter, 2022-11-17 [InstanceEdit:9820650] D'Eustachio, Peter, 2022-11-17 [InstanceEdit:9820652] D'Eustachio, Peter, 2022-11-18 [InstanceEdit:9828534] D'Eustachio, Peter, 2023-02-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9933517] Stephan, Ralf, 2025-01-01 name HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:30537] G6P [cytosol] [SimpleEntity:70106] H+ [cytosol] precedingEvent
releaseDate 2004-07-06 reviewed [InstanceEdit:9820651] Hill, David P, 2022-11-18 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:450087] D'Eustachio, P, 2009-12-11 [InstanceEdit:9820650] D'Eustachio, Peter, 2022-11-17 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:361792] R-HSA-70420.7 summation [Summation:391482] Cytosolic glucokinase and the three isoforms of hexokinase c... (hasEvent) [Pathway:70171] Glycolysis [Homo sapiens] (normalReaction) [FailedReaction:5621888] Defective HK1 does not phosphorylate Glc to form G6P [Homo sapiens] [FailedReaction:5621918] Defective GCK does not phosphorylate Glc to form G6P [Homo sapiens] (precedingEvent) [Reaction:70377] G6PD multimers dehydrogenate G6P [Homo sapiens] [Reaction:70471] GPI dimer isomerizes G6P [Homo sapiens] [Reaction:8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP [Homo sapiens] [Reaction:9638127] PGM1:Mg2+ isomerises G6P to G1P [Homo sapiens] (replacementInstances) [_Deleted:450105] Deletion of instances: 70414, 70397, 70380 [_Deleted:450107] Deletion of instance: 70114 [_Deleted:622426] Deletion of instance: 500039 [_Deleted:622430] Deletion of instance: 500039 (updatedInstance) [_UpdateTracker:9777234] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v72:[addOutput] [_UpdateTracker:9790504] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v33:[addLiteratureReference, modifyText] [_UpdateTracker:9791235] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9791584] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v28:[addLiteratureReference, add_removeSummation] [_UpdateTracker:9792318] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v22:[addLiteratureReference] [_UpdateTracker:9846610] Update Tracker - [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - v84:[addLiteratureReference, modifyText]
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