Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Tetrameric GLUT2, the SLC2A2 gene product, associated with t...
| Class:Id | Summation:70405 |
|---|---|
| _displayName | Tetrameric GLUT2, the SLC2A2 gene product, associated with t... |
| _timestamp | 2017-03-10 19:15:56 |
| modified | [InstanceEdit:199720] D'Eustachio, P, 2007-07-11 20:28:53 [InstanceEdit:450085] D'Eustachio, P, 2009-12-11 [InstanceEdit:6789777] Jassal, Bijay, 2015-08-04 [InstanceEdit:8981563] D'Eustachio, Peter, 2017-03-10 |
| text | Tetrameric GLUT2, the SLC2A2 gene product, associated with the plasma membrane, mediates the facilitated diffusion of glucose (Glc) into cells. GLUT2 is expressed on hepatocytes and pancreatic beta cells, and on the basolateral surfaces of enterocytes in the small intestine. Because of its high Km for glucose (~15-20 mM), GLUT2-mediated glucose uptake increases proportionally with increase of blood glucose concentration after a meal. This feature of the transporter is thought to enable efficient uptake of large amounts of glucose by the liver in the fed state, and to allow it to function as part of a glucose sensor coupled to insulin release in pancreatic beta cells (Thorens 2001). GLUT2 also mediates glucose export from liver cells when gluconeogenesis is underway (Colville et al. 1993; Santer et al. 1997; Wu et al. 1998). GLUT2 on enterocytes mediates the release of dietary glucose, galactose, and fructose into the circulation. This activity is annotated as part of the intestinal absorption module. Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS). It is characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose (Burwinkel et al. 1999). |
| (summation) | [Reaction:8981574] GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Tetrameric GLUT2, the SLC2A2 gene product, associated with t... (70405)
