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Details on Person GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc

Class:Id	Reaction:70369
_displayName	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc
_doRelease	TRUE
_timestamp	2025-01-23 15:40:57
catalystActivity	[CatalystActivity:70368] UDP-glucose 4-epimerase activity of GALE:NAD+ dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643941] UDP-glucose 4-epimerase activity of GALE:NAD+ dimer [cytosol] Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9936200] RHEA:22170
input	[SimpleEntity:29452] UDP-Gal [cytosol]
internalReviewed	[InstanceEdit:9936141] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:199728] Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase [LiteratureReference:476575] Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:199725] D'Eustachio, P, 2007-07-11 20:42:37 [InstanceEdit:476573] D'Eustachio, P, 2010-01-26 [InstanceEdit:1442515] D'Eustachio, P, 2011-07-12 [InstanceEdit:5610086] Jassal, Bijay, 2014-07-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9936201] Rothfels, Karen, 2025-01-21 [InstanceEdit:9936511] Rothfels, Karen, 2025-01-23
name	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc UDP-alpha-D-galactose=> UDP-alpha-D-glucose UDP-galactose <=> UDP-glucose
output	[SimpleEntity:29410] UDP-Glc [cytosol]
precedingEvent	[Reaction:70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal [Homo sapiens] [Reaction:70355] GALK1 phosphorylates Gal to Gal1P [Homo sapiens] [Reaction:70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:9936506] D'Eustachio, Peter, 2025-01-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361189] R-HSA-70369.5
summation	[Summation:179285] Cytosolic UDP-galactose 4-epimerase catalyzes the interconve...
(hasEvent)	[Pathway:70370] Galactose catabolism [Homo sapiens]
(normalReaction)	[FailedReaction:5610036] Defective GALE does not epimerise UDP-Gal to UDP-Glc [Homo sapiens]
(precedingEvent)	[Reaction:70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785338] Update Tracker - [Reaction:70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc - v52:[modifyText] [_UpdateTracker:9790819] Update Tracker - [Reaction:70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792322] Update Tracker - [Reaction:70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc - v22:[addLiteratureReference]
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