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Details on Person GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal

Class:Id	Reaction:70361
_displayName	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal
_doRelease	TRUE
_timestamp	2025-01-23 15:41:38
authored	[InstanceEdit:70156] 2003-02-25 00:00:00
catalystActivity	[CatalystActivity:70360] UDP-glucose:hexose-1-phosphate uridylyltransferase activity of GALT [cytosol]
catalystActivityReference	[CatalystActivityReference:9643662] UDP-glucose:hexose-1-phosphate uridylyltransferase activity of GALT [cytosol] Molecular characterization of two galactosemia mutations: correlation of mutations with highly conserved domains in galactose-1-phosphate uridyl transferase
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9936199] RHEA:13990
input	[SimpleEntity:29410] UDP-Glc [cytosol] [SimpleEntity:30170] Gal1P [cytosol]
internalReviewed	[InstanceEdit:9936141] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:178112] Molecular characterization of two galactosemia mutations: correlation of mutations with highly conserved domains in galactose-1-phosphate uridyl transferase [LiteratureReference:5678635] Molecular basis of galactosemia: mutations and polymorphisms in the gene encoding human galactose-1-phosphate uridylyltransferase
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:178110] D'Eustachio, P, 2006-04-14 23:31:00 [InstanceEdit:453123] D'Eustachio, P, 2010-01-18 [InstanceEdit:476573] D'Eustachio, P, 2010-01-26 [InstanceEdit:5610086] Jassal, Bijay, 2014-07-21 [InstanceEdit:5678623] Jassal, Bijay, 2015-02-25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9936201] Rothfels, Karen, 2025-01-21 [InstanceEdit:9936514] Rothfels, Karen, 2025-01-23
name	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal alpha-D-galactose 1-phosphate + UDP-alpha-D_glucose <=> alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
output	[SimpleEntity:29548] G1P [cytosol] [SimpleEntity:29452] UDP-Gal [cytosol]
precedingEvent	[Reaction:70355] GALK1 phosphorylates Gal to Gal1P [Homo sapiens] [Reaction:9931853] GALM converts beta-D-GAL to alpha-D-GAL [Homo sapiens] [Reaction:70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc [Homo sapiens] [Reaction:70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:9936506] D'Eustachio, Peter, 2025-01-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361362] R-HSA-70361.5
summation	[Summation:71612] Cytosolic galactose-1-phosphate uridylyltransferase (GALT) c...
(hasEvent)	[Pathway:70370] Galactose catabolism [Homo sapiens]
(normalReaction)	[FailedReaction:5610038] Defective GALT does not transfer UMP to Gal1P [Homo sapiens]
(precedingEvent)	[Reaction:70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc [Homo sapiens] [Reaction:9638125] PGM1:Mg2+ isomerises G1P to G6P [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785485] Update Tracker - [Reaction:70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal - v52:[addLiteratureReference, modifyText] [_UpdateTracker:9790909] Update Tracker - [Reaction:70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal - v32:[modifyText]
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