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Details on Person GALK1 phosphorylates Gal to Gal1P

Class:IdReaction:70355
_displayNameGALK1 phosphorylates Gal to Gal1P
_doReleaseTRUE
_timestamp2025-01-23 15:41:13
catalystActivity[CatalystActivity:70354] galactokinase activity of GALK1 [cytosol]
catalystActivityReference[CatalystActivityReference:9643698] galactokinase activity of GALK1 [cytosol] Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2
compartment[Compartment:70101] cytosol
crossReference[DatabaseIdentifier:9936194] RHEA:13553
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:9931851] alpha-D-Gal [cytosol]
internalReviewed[InstanceEdit:9936141] D'Eustachio, Peter, 2025-01-20
literatureReference[LiteratureReference:199732] Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2
modified[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:199725] D'Eustachio, P, 2007-07-11 20:42:37
[InstanceEdit:476573] D'Eustachio, P, 2010-01-26
[InstanceEdit:5610086] Jassal, Bijay, 2014-07-21
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9658417] D'Eustachio, Peter, 2019-08-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9931862] Rothfels, Karen, 2024-12-13
[InstanceEdit:9936201] Rothfels, Karen, 2025-01-21
[InstanceEdit:9936512] Rothfels, Karen, 2025-01-23
nameGALK1 phosphorylates Gal to Gal1P
ATP + alpha-D-galactose => ADP + alpha-D-galactose 1-phosphate + H(+)
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:30170] Gal1P [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9936506] D'Eustachio, Peter, 2025-01-23
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361446] R-HSA-70355.6
structureModified[InstanceEdit:9931862] Rothfels, Karen, 2024-12-13
[InstanceEdit:9936201] Rothfels, Karen, 2025-01-21
summation[Summation:178499] Cytosolic galactokinase (GALK1) catalyses the reaction of AT...
(hasEvent)[Pathway:70370] Galactose catabolism [Homo sapiens]
(normalReaction)[FailedReaction:5610026] Defective GALK1 does not phosphorylate Gal [Homo sapiens]
(precedingEvent)[Reaction:70361] GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786209] Update Tracker - [Reaction:70355] GALK1 phosphorylates Gal to Gal1P - v50:[modifyText]
[_UpdateTracker:9790839] Update Tracker - [Reaction:70355] GALK1 phosphorylates Gal to Gal1P - v32:[modifyText]
[_UpdateTracker:9792395] Update Tracker - [Reaction:70355] GALK1 phosphorylates Gal to Gal1P - v22:[addLiteratureReference]
[_UpdateTracker:9939784] Update Tracker - [Reaction:70355] GALK1 phosphorylates Gal to Gal1P - v92:[add_removeInput, removeOutput]
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