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Details on Person ALDOB tetramer cleaves Fru-1-P to GA and DHAP

Class:IdReaction:70342
_displayNameALDOB tetramer cleaves Fru-1-P to GA and DHAP
_doReleaseTRUE
_timestamp2023-05-30 20:57:04
authored[InstanceEdit:6792817] Cameselle, José Carlos, Ribeiro, João Meireles, 2015-08-27
catalystActivity[CatalystActivity:469725] fructose-1-phosphate aldolase activity of ALDOB tetramer [cytosol]
catalystActivityReference[CatalystActivityReference:9643054] fructose-1-phosphate aldolase activity of ALDOB tetramer [cytosol] Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host
compartment[Compartment:70101] cytosol
edited[InstanceEdit:5652219] D'Eustachio, Peter, 2014-11-28
input[SimpleEntity:9832976] beta-D-Fru 1-P [cytosol]
literatureReference[LiteratureReference:5675300] Hereditary fructose intolerance
[LiteratureReference:469723] The structure of human liver fructose-1,6-bisphosphate aldolase
[LiteratureReference:469709] [The metabolism of fructose-1-phosphate in the liver.]
[LiteratureReference:6792815] Distribution of fructose diphosphate aldolase variants in biological systems
[LiteratureReference:6792827] Isolation of fructose diphosphate aldolases A, B, and C
[LiteratureReference:5675809] Kinetic and immunological abnormalities of aldolase B in hereditary fructose intolerance
[LiteratureReference:469704] Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene
modified[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:166004] Gopinathrao, G, 2005-08-12 11:14:59
[InstanceEdit:179512] D'Eustachio, P, 2006-05-05 15:55:03
[InstanceEdit:464980] D'Eustachio, P, 2010-01-24
[InstanceEdit:469706] D'Eustachio, P, 2010-01-25
[InstanceEdit:5652053] D'Eustachio, Peter, 2014-11-26
[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
[InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
[InstanceEdit:5675277] D'Eustachio, Peter, 2015-02-15
[InstanceEdit:5675813] D'Eustachio, Peter, 2015-02-16
[InstanceEdit:6792826] D'Eustachio, Peter, 2015-08-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9670648] D'Eustachio, Peter, 2019-12-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9832974] D'Eustachio, Peter, 2023-04-11
[InstanceEdit:9835574] D'Eustachio, Peter, 2023-05-16
[InstanceEdit:9836604] D'Eustachio, Peter, 2023-05-30
nameALDOB tetramer cleaves Fru-1-P to GA and DHAP
beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate
Aldolase B (ALDOB) cleaves fructose-1-phosphate to form D-glyceraldehyde and dihydroxyacetone phosphate
D-fructose-1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate
output[SimpleEntity:30393] GA [cytosol]
[SimpleEntity:75970] DHAP [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2004-07-06
reviewed[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29
[InstanceEdit:9835575] Hill, David P, 2023-05-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
[InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358765] R-HSA-70342.7
structureModified[InstanceEdit:9832974] D'Eustachio, Peter, 2023-04-11
summation[Summation:178629] Cytosolic aldolase B (ALDOB) catalyzes the reaction of D-fru...
(hasEvent)[Pathway:70350] Fructose catabolism [Homo sapiens]
(normalReaction)[FailedReaction:5656438] Defective ALDOB does not cleave Fru 1-P to GA and DHAP [Homo sapiens]
(precedingEvent)[Reaction:70349] DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate [Homo sapiens]
[Reaction:70454] TPI1 dimer isomerizes DHAP to GA3P [Homo sapiens]
[Reaction:6813749] ALDH1A1 oxidises GA to DGA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784154] Update Tracker - [Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP - v54:[addLiteratureReference, modifyText]
[_UpdateTracker:9784943] Update Tracker - [Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP - v52:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9790892] Update Tracker - [Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP - v32:[addCatalystActivity, add_removeLiteratureReference, modifyText]
[_UpdateTracker:9835733] Update Tracker - [Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP - v85:[add_removeInput]
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