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Details on Person KHK dimer phosphorylates Fru to Fru 1-P

Class:Id	Reaction:70333
_displayName	KHK dimer phosphorylates Fru to Fru 1-P
_doRelease	TRUE
_timestamp	2023-05-30 20:57:13
authored	[InstanceEdit:6792817] Cameselle, Jos� Carlos, Ribeiro, Jo�o Meireles, 2015-08-27
catalystActivity	[CatalystActivity:70330] ketohexokinase activity of KHK dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643327] ketohexokinase activity of KHK dimer [cytosol] Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria
compartment	[Compartment:70101] cytosol
edited	[InstanceEdit:5652219] D'Eustachio, Peter, 2014-11-28
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:9832977] beta-D-Fru [cytosol]
literatureReference	[LiteratureReference:5652057] Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria [LiteratureReference:469711] Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase) [LiteratureReference:5675279] Both isoforms of ketohexokinase are dispensable for normal growth and development [LiteratureReference:5675309] Genes required for fructose metabolism are expressed in Purkinje cells in the cerebellum [LiteratureReference:5675305] Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice [LiteratureReference:469724] Structures of alternatively spliced isoforms of human ketohexokinase
modified	[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:167173] D'Eustachio, P, 2005-10-11 12:29:18 [InstanceEdit:469706] D'Eustachio, P, 2010-01-25 [InstanceEdit:5652053] D'Eustachio, Peter, 2014-11-26 [InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29 [InstanceEdit:5675277] D'Eustachio, Peter, 2015-02-15 [InstanceEdit:5675813] D'Eustachio, Peter, 2015-02-16 [InstanceEdit:6792826] D'Eustachio, Peter, 2015-08-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9670648] D'Eustachio, Peter, 2019-12-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9832974] D'Eustachio, Peter, 2023-04-11 [InstanceEdit:9835574] D'Eustachio, Peter, 2023-05-16 [InstanceEdit:9836604] D'Eustachio, Peter, 2023-05-30
name	KHK dimer phosphorylates Fru to Fru 1-P ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+) Ketohexokinase (KHK) phosphorylates beta-D-fructose to form fructose 1-phosphate ATP + beta-D-fructose => ADP + D-fructose 1-phosphate
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:9832976] beta-D-Fru 1-P [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:5652195] SORD oxidizes D-sorbitol to Fru [Homo sapiens] [Reaction:5652172] AKR1B1 reduces Glc to D-sorbitol [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:70334] Negative regulation by 'ADP [cytosol]' [PositiveRegulation:9034472] Positive regulation by 'K+ [cytosol]'
releaseDate	2004-07-06
reviewed	[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:9835575] Hill, David P, 2023-05-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24 [InstanceEdit:5668966] D'Eustachio, Peter, 2015-01-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359159] R-HSA-70333.8
structureModified	[InstanceEdit:9832974] D'Eustachio, Peter, 2023-04-11
summation	[Summation:178494] Cytosolic ketohexokinase (KHK, also known as fructokinase) c...
(hasEvent)	[Pathway:70350] Fructose catabolism [Homo sapiens]
(normalReaction)	[FailedReaction:5656459] Defective KHK does not phosphorylate beta-D-fructose [Homo sapiens]
(precedingEvent)	[Reaction:70342] ALDOB tetramer cleaves Fru-1-P to GA and DHAP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779993] Update Tracker - [Reaction:70333] KHK dimer phosphorylates Fru to Fru 1-P - v64:[addRegulator] [_UpdateTracker:9784192] Update Tracker - [Reaction:70333] KHK dimer phosphorylates Fru to Fru 1-P - v54:[modifyText] [_UpdateTracker:9785083] Update Tracker - [Reaction:70333] KHK dimer phosphorylates Fru to Fru 1-P - v52:[addLiteratureReference, modifyText] [_UpdateTracker:9790997] Update Tracker - [Reaction:70333] KHK dimer phosphorylates Fru to Fru 1-P - v32:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9835711] Update Tracker - [Reaction:70333] KHK dimer phosphorylates Fru to Fru 1-P - v85:[add_removeInput, add_removeOutput]
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