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Details on Person UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose

Class:Id	Reaction:70286
_displayName	UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose
_doRelease	TRUE
_timestamp	2024-12-11 20:54:08
catalystActivity	[CatalystActivity:70285] UTP:glucose-1-phosphate uridylyltransferase activity of 8xUGP2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643272] UTP:glucose-1-phosphate uridylyltransferase activity of 8xUGP2 [cytosol] Uridine diphosphate glucose pyrophosphorylase. IV. Crystallization and properties of the enzyme from human liver
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9912884] RHEA:19890
input	[SimpleEntity:29494] UTP [cytosol] [SimpleEntity:29548] G1P [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9913491] D'Eustachio, Peter, 2024-06-14
literatureReference	[LiteratureReference:70322] Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli. [LiteratureReference:453146] Uridine diphosphate glucose pyrophosphorylase. IV. Crystallization and properties of the enzyme from human liver [LiteratureReference:453130] Uridine diphosphate glucose pyrophosphorylase. II
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:174378] Jassal, Bijay, 2006-02-17 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:453123] D'Eustachio, P, 2010-01-18 [InstanceEdit:453319] D'Eustachio, P, 2010-01-21 [InstanceEdit:453352] D'Eustachio, P, 2010-01-21 [InstanceEdit:482756] D'Eustachio, P, 2010-01-28 [InstanceEdit:482757] D'Eustachio, P, 2010-01-28 [InstanceEdit:482758] D'Eustachio, P, 2010-01-28 [InstanceEdit:482759] D'Eustachio, P, 2010-01-28 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9639386] Jassal, Bijay, 2019-03-11 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9772121] D'Eustachio, Peter, 2022-04-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9912893] D'Eustachio, Peter, 2024-06-10 [InstanceEdit:9913490] D'Eustachio, Peter, 2024-06-14 [InstanceEdit:9916040] D'Eustachio, Peter, 2024-07-19 [InstanceEdit:9918570] Matthews, Lisa, 2024-08-16 [InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
name	UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose alpha-D-glucose 1-phosphate + UTP + H(+) => UDP-alpha-D-glucose + diphosphate
negativePrecedingEvent	[NegativePrecedingEvent:9931453] Abundant Molecules: glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] [NegativePrecedingEvent:9931473] Abundant Molecules: poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] [NegativePrecedingEvent:9931452] Abundant Molecules: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
output	[SimpleEntity:111294] PPi [cytosol] [SimpleEntity:29410] UDP-Glc [cytosol]
precedingEvent	[Reaction:71590] glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] [Homo sapiens] [Reaction:71588] glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP [Homo sapiens] [Reaction:9638127] PGM1:Mg2+ isomerises G6P to G1P [Homo sapiens] [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:9916041] Hill, David P, 2024-07-19
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:453329] D'Eustachio, P, 2010-01-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360250] R-HSA-70286.7
structureModified	[InstanceEdit:9912893] D'Eustachio, Peter, 2024-06-10
summation	[Summation:179331] Cytosolic UDP-glucose pyrophosphorylase 2 (UGP2) catalyzes t...
(hasEvent)	[Pathway:173599] Formation of the active cofactor, UDP-glucuronate [Homo sapiens] [Pathway:3322077] Glycogen synthesis [Homo sapiens]
(inferredFrom)	[Reaction:1113187] UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose [Oryza sativa]
(orthologousEvent)	[Reaction:1113187] UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose [Oryza sativa]
(precedingEvent)	[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens] [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate [Homo sapiens] [Reaction:3322003] Autoglucosylation of GYG1 complexed with GYS1-b [Homo sapiens] [Reaction:3322014] Autoglucosylation of GYG2 complexed with GYS2-a [Homo sapiens] [Reaction:3322019] Autoglucosylation of GYG2 complexed with GYS2-b [Homo sapiens] [Reaction:3322025] Autoglucosylation of GYG1 complexed with GYS1-a [Homo sapiens] [NegativePrecedingEvent:9931449] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose [NegativePrecedingEvent:9931458] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose [NegativePrecedingEvent:9931460] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose [NegativePrecedingEvent:9931470] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose List all 11 refering instances
(replacementInstances)	[_Deleted:453148] Deletion of instance: 71562 [_Deleted:453150] Deletion of instance: 70271
(updatedInstance)	[_UpdateTracker:9791036] Update Tracker - [Reaction:70286] UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose - v32:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9791785] Update Tracker - [Reaction:70286] UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose - v25:[modifyText] [_UpdateTracker:9919386] Update Tracker - [Reaction:70286] UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose - v90:[removeInput]
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No pathways have been reviewed or authored by UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose (70286)