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Details on Person PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate

Class:Id	Reaction:70262
_displayName	PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate
_doRelease	TRUE
_timestamp	2025-01-01 11:06:32
catalystActivity	[CatalystActivity:177980] fructose-2,6-bisphosphate 2-phosphatase activity of p-PFKFB1 dimer [cytosol]
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9933530] RHEA:17290
goBiologicalProcess	[GO_BiologicalProcess:24887] negative regulation of glycolytic process
input	[SimpleEntity:30533] D-Fructose 2,6-bisphosphate [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:70163] 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:177978] Matthews, L, 2006-04-14 06:50:12 [InstanceEdit:376864] D'Eustachio, P, 2008-09-09 21:34:14 [InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8982493] D'Eustachio, Peter, 2017-03-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
name	PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
output	[SimpleEntity:29512] Fru(6)P [cytosol] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2004-07-06
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360409] R-HSA-70262.5
summation	[Summation:178796] The fructose 2,6-bisphosphatase activity of cytosolic phosph...
(hasEvent)	[Pathway:9634600] Regulation of glycolysis by fructose 2,6-bisphosphate metabolism [Homo sapiens]
(replacementInstances)	[_Deleted:372876] Deletion of instance: 71805 [_Deleted:617380] Deletion of instances: 71809, 71807, 71803
(updatedInstance)	[_UpdateTracker:9791767] Update Tracker - [Reaction:70262] Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate - v26:[modifyText]
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No pathways have been reviewed or authored by PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (70262)