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Details on Person PCK1 phosphorylates OA to yield PEP

Class:Id	Reaction:70241
_displayName	PCK1 phosphorylates OA to yield PEP
_doRelease	TRUE
_timestamp	2025-01-02 09:29:09
catalystActivity	[CatalystActivity:70496] phosphoenolpyruvate carboxykinase (GTP) activity of PCK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9815676] phosphoenolpyruvate carboxykinase (GTP) activity of PCK1 [cytosol] Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9933539] RHEA:10389
input	[SimpleEntity:76213] OA [cytosol] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:198519] Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
modified	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:177982] Matthews, L, 2006-04-14 06:50:45 [InstanceEdit:198480] D'Eustachio, P, 2007-06-22 14:17:01 [InstanceEdit:198534] D'Eustachio, P, 2007-06-22 15:53:40 [InstanceEdit:198551] D'Eustachio, P, 2007-06-22 16:17:09 [InstanceEdit:372822] D'Eustachio, P, 2008-07-03 22:07:04 [InstanceEdit:372849] D'Eustachio, P, 2008-07-07 20:55:07 [InstanceEdit:376871] D'Eustachio, P, 2008-09-10 19:02:07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9815667] D'Eustachio, Peter, 2022-08-25 [InstanceEdit:9815858] D'Eustachio, Peter, 2022-08-29 [InstanceEdit:9815861] D'Eustachio, Peter, 2022-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857024] Stephan, Ralf, 2023-12-30 [InstanceEdit:9933541] Stephan, Ralf, 2025-01-02
name	PCK1 phosphorylates OA to yield PEP GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate
output	[SimpleEntity:29492] PEP [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:372448] SLC25A12,13 exchange L-Glu and L-Asp [Homo sapiens] [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate [Homo sapiens] [Reaction:6797627] ASPG hydrolyses L-Asn to L-Asp [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12 [InstanceEdit:9815859] Hill, David P, 2022-08-29
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361642] R-HSA-70241.6
summation	[Summation:70242] The transfer of a high-energy phosphate bond from GTP to oxa...
(hasEvent)	[Pathway:70263] Gluconeogenesis [Homo sapiens]
(precedingEvent)	[Reaction:70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791727] Update Tracker - [Reaction:70241] oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] - v26:[modifyText] [_UpdateTracker:9792327] Update Tracker - [Reaction:70241] oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] - v22:[addLiteratureReference, add_removeCatalystActivity, modifyText] [_UpdateTracker:9846944] Update Tracker - [Reaction:70241] PCK1 phosphorylates OA to yield PEP - v83:[modifyText]
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