Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person PDH complex [mitochondrial matrix]

Class:IdComplex:70070
_displayNamePDH complex [mitochondrial matrix]
_timestamp2024-02-21 17:03:39
compartment[Compartment:5460] mitochondrial matrix
goCellularComponent[GO_CellularComponent:19468] pyruvate dehydrogenase complex
hasComponent
literatureReference[LiteratureReference:69983] Structure-function relationships in dihydrolipoamide acyltransferases
[LiteratureReference:69972] The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes
[LiteratureReference:70060] Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex
[LiteratureReference:70066] Pyruvate dehydrogenase E3 binding protein deficiency
[LiteratureReference:450837] Mutations in the X-linked pyruvate dehydrogenase (E1) alpha subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency
modified[InstanceEdit:2129345] D'Eustachio, P, 2012-02-20
[InstanceEdit:6792676] Jassal, Bijay, 2015-08-25
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9715688] Shorser, Solomon, 2021-02-17
[InstanceEdit:9729976] Shorser, Solomon, 2021-05-05
[InstanceEdit:9750461] Weiser, JD, 2021-08-11
[InstanceEdit:9757984] Weiser, JD, 2021-11-08
[InstanceEdit:9767390] Wright, Adam, 2022-02-25
[InstanceEdit:9773515] Weiser, Joel, 2022-05-04
[InstanceEdit:9861969] Stephan, Ralf, 2024-02-21
[InstanceEdit:9909910] Weiser, Joel, 2024-05-14
[InstanceEdit:9910117] Weiser, Joel, 2024-05-14
[InstanceEdit:9917728] Weiser, Joel, 2024-08-09
[InstanceEdit:9926726] Weiser, Joel, 2024-11-03
[InstanceEdit:9939161] Weiser, Joel, 2025-02-21
[InstanceEdit:9948552] Weiser, Joel, 2025-05-21
[InstanceEdit:9963749] Weiser, Joel, 2025-08-15
[InstanceEdit:9970792] Weiser, Joel, 2025-10-31
[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
namePDH complex
pyruvate dehydrogenase complex
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:362334] R-HSA-70070.21
(input)[Reaction:203946] PDK isozymes phosphorylate PDHC subunit E1 [Homo sapiens]
(output)[Reaction:204169] PDP1,2 dephosphorylate p-lipo-PDH [Homo sapiens]
(physicalEntity)[CatalystActivity:450854] pyruvate dehydrogenase (acetyl-transferring) activity of PDH complex [mitochondrial matrix]
[CatalystActivity:9861662] dihydrolipoyllysine-residue acetyltransferase activity of PDH complex [mitochondrial matrix]
[CatalystActivity:9861687] dihydrolipoyl dehydrogenase (NADH) activity of PDH complex [mitochondrial matrix]
(replacementInstances)[_Deleted:450857] Deletion of instance: 70074
[_Deleted:450859] Deletion of instance: 70085
[_Deleted:450860] Deletion of instance: 70083
[_Deleted:450861] Deletion of instance: 70079
(updatedInstance)[_UpdateTracker:9866595] Update Tracker - [Complex:70070] PDH complex [mitochondrial matrix] - v24:[updateContainedComponent]
[_UpdateTracker:9869934] Update Tracker - [Complex:70070] PDH complex [mitochondrial matrix] - v36:[updateContainedComponent]
[_UpdateTracker:9892593] Update Tracker - [Complex:70070] PDH complex [mitochondrial matrix] - v54:[addName, updateContainedComponent]
[_UpdateTracker:9896094] Update Tracker - [Complex:70070] PDH complex [mitochondrial matrix] - v60:[updateContainedComponent]
[Change default viewing format]
No pathways have been reviewed or authored by PDH complex [mitochondrial matrix] (70070)