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Details on Person Lipo-K105-DBT [mitochondrial matrix]

Class:IdEntityWithAccessionedSequence:70017
_displayNameLipo-K105-DBT [mitochondrial matrix]
_timestamp2024-01-14 09:24:56
compartment[Compartment:5460] mitochondrial matrix
endCoordinate482
hasModifiedResidue[ModifiedResidue:508256] N6-lipoyl-L-lysine at 105
literatureReference[LiteratureReference:508263] Differential processing of human and rat E1 alpha precursors of the branched-chain alpha-keto acid dehydrogenase complex caused by an N-terminal proline in the rat sequence
[LiteratureReference:508260] Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex
modified[InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08
[InstanceEdit:508257] D'Eustachio, P, 2010-02-11
[InstanceEdit:3632907] Wu, G, 2013-05-28
[InstanceEdit:6792676] Jassal, Bijay, 2015-08-25
[InstanceEdit:9858750] Stephan, Ralf, 2024-01-14
nameLipo-K105-DBT
dihydrolipoamide branched chain transacylase E2
DBT
referenceEntity[ReferenceGeneProduct:60856] UniProt:P11182 DBT [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:369123] R-HSA-70017.3
startCoordinate62
(activeUnit)[CatalystActivity:9859164] acyltransferase activity, transferring groups other than amino-acyl groups of BCKDH [mitochondrial matrix]
(hasComponent)[Complex:70019] BCKDH [mitochondrial matrix] [Homo sapiens]
[Complex:5693120] p-BCKDH [mitochondrial matrix] [Homo sapiens]
[Complex:9865104] mutant BCKDHA-BCKDH [mitochondrial matrix] [Homo sapiens]
[Complex:9907590] DLD mutant-BCKDH [mitochondrial matrix] [Homo sapiens]
(hasMember)[DefinedSet:6792580] Lipoylated DBT/DLST [mitochondrial matrix] [Homo sapiens]
(input)[Reaction:9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV [Homo sapiens]
[FailedReaction:9865121] BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA [Homo sapiens]
(output)[Reaction:9859172] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens]
(replacementInstances)[_Deleted:508270] Deletion of instances: 70056, 70048, 70038, 70035, 70018
(updatedInstance)[_UpdateTracker:9868795] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v32:[addHasModifiedResidue, addLiteratureReference, modifyEndCoordinate, modifyName, modifyStartCoordinate]
[_UpdateTracker:9882196] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v45:[addName]
[_UpdateTracker:9892988] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v54:[modifyName]
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No pathways have been reviewed or authored by Lipo-K105-DBT [mitochondrial matrix] (70017)